From - Tue Nov 17 11:22:01 1998 X-Mozilla-Status: 0001 Message-ID: <3651A2A4.89807EF4@mit.edu> Date: Tue, 17 Nov 1998 11:21:57 -0500 From: CarolYN J Smith Organization: Massachusetts Institute of Technology X-Mailer: Mozilla 4.05 [en] (X11; U; SunOS 5.6 sun4m) MIME-Version: 1.0 To: emee@cubist.com, cjsmith@mit.edu Subject: Resume Submission Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit Dear Sir or Madam, I am interested in job opportunities within your company. I have extensive experience in protein chemistry, cellular biology and enzyme kinetics. Most recently I have set up and run an enzyme kinetics laboratory to facilitate testing of novel protease inhibitors. I have attached my resume below, please contact me at cjsmith@mit.edu or (617) 628-0406 with questions or to set up an interview. Thank you. Sincerely, Carolyn Smith Carolyn Jean Smith Home Address Phone and Email 76 Lexington Ave Apt 1 (617) 628-0406 Somerville, MA 02144 cjsmith@mit.edu Experience Arqule Corporation and Brandeis University 1996--present As consultant to Arqule Corporation and Visiting Scientist at Brandeis, worked on a joint project between Arqule Corporation and Brandeis on a project involving synthesis of novel protease inhibitors. Designed an enzyme kinetics laboratory; developed and ran assays to test synthetic inhibitors of thrombin; performed and presented kinetic analyses of the results. Dana Farber Cancer Institute, Dept. of Cancer Pharmacology 1996--present Under the direction of Dr. Miyako Abe, cultured MCF-7 cells and purified DF3 protein for use in research into the role of DF3 in cellular function. Techniques included cell culture, FPLC, Western immunoblotting, plasmid transfection, and affinity chromatography. Tufts University, Dept. of Anatomy and Cell Biology 1995 Held the position of research technician under the direction of Dr. Mary K. Murray. Techniques included lectin chromatography and electrophoresis, DNA cloning, PCR, and DNA sequencing. Massachusetts General Hospital, Dept. of Hematology-Oncology, and Brigham and Women's Hospital, Dept. of Experimental Medicine 1987--1994 Held the position of research technologist under the direction of Dr. Stuart Lind. Responsibilities: Safety Officer, Radiation Safety Officer, lab management, and conducting experiments. Techniques included protein purification, affinity and ion exchange chromatography, ELISAs, SDS-PAGE, immunoblots, antibody preparation, small animal surgery, histological staining of rat and human tissue preparations, enzyme kinetics experiments (synthetic substrate assays), fibrinolysis experiments using fibrinogen or whole plasma and I125, and cell culture. Massachusetts Institute of Technology, Biotechnology Lab 1986 Studied the interaction of phosphoprotein 53 and large T-antigen in a temperature-sensitive rat embryo neural crest cell line, and investigated the relationship of these proteins to cellular differentiation. Publications ``Actin Stimulates Plasmin Generation by Tissue and Urokinase-Type Plasminogen Activators,'' by Stuart E. Lind and Carolyn J. Smith. Archives of Biochemistry and Biophysics, vol. 307, no. 1, Nov. 15, 1993. ``Oxidative Inactivation of Plasmin and Other Serine Proteases by Copper and Ascorbate,'' by Stuart E. Lind, Jonathan R. McDonagh, and Carolyn J. Smith. Blood, vol. 82, no. 5, Sept. 1, 1993. ``Actin Accelerates Plasmin Generation by Tissue Plasminogen Activator,'' by Stuart E. Lind and Carolyn J. Smith. Journal of Biological Chemistry, vol. 226, no. 26, Sept. 15, 1991. ``Actin Is a Noncompetitive Plasmin Inhibitor,'' by Stuart E. Lind and Carolyn J. Smith. Journal of Biological Chemistry, vol. 266, no. 8, March 15, 1991. Education Massachusetts Institute of Technology, B.S., Life Sciences, 1987 From - Tue Nov 17 11:33:08 1998 X-Mozilla-Status: 0001 Message-ID: <3651A542.8D91D3A1@mit.edu> Date: Tue, 17 Nov 1998 11:33:06 -0500 From: CarolYN J Smith Organization: Massachusetts Institute of Technology X-Mailer: Mozilla 4.05 [en] (X11; U; SunOS 5.6 sun4m) MIME-Version: 1.0 To: employment@dyax.com, cjsmith@mit.edu Subject: Job Opportunity Information Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit Dear Sir or Madam, I am interested in job opportunities within your company. My resume is available online at http://www.mit.edu/~cjsmith/resume.html. I am looking for a research scientist position. Thank you. Sincerely, Carolyn Smith From - Tue Nov 17 11:42:15 1998 X-Mozilla-Status: 0001 Message-ID: <3651A766.77680564@mit.edu> Date: Tue, 17 Nov 1998 11:42:14 -0500 From: CarolYN J Smith Organization: Massachusetts Institute of Technology X-Mailer: Mozilla 4.05 [en] (X11; U; SunOS 5.6 sun4m) MIME-Version: 1.0 To: hr@interneuron.com, cjsmith@mit.edu Subject: Job Opportunities Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit Dear Ms Cooper, I am interested in job opportunities within Interneuron Pharmaceuticals. My resume can be seen online at http://www.mit.edu/~cjsmith/resume.html. I am looking for a position as associate scientist. Thank you very much for your time. Sincerely, Carolyn Smith From - Tue Nov 17 11:54:25 1998 X-Mozilla-Status: 0001 Message-ID: <3651AA3F.9B0D040A@mit.edu> Date: Tue, 17 Nov 1998 11:54:23 -0500 From: CarolYN J Smith Organization: Massachusetts Institute of Technology X-Mailer: Mozilla 4.05 [en] (X11; U; SunOS 5.6 sun4m) MIME-Version: 1.0 To: personnel@leukosite.com, cjsmith@mit.edu Subject: Job Opportunities Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit Dear Sir or Madam, I am interested in job opportunities within your company. I have extensive laboratiry experience, most recently in the areas of enzyme kinetics and cellular biology. I have inclosed my resume below, please contact me with any questions. I can be reached at cjsmith@mit.edu or by phone at (617) 628-0406. Thank you. Sincerely, Carolyn Smith ----------------- Carolyn Jean Smith Home Address Phone and Email 76 Lexinton Ave. Apt. 1 (627) 628-0406 Somerville, MA 02144 cjsmith@mit.edu Experience Arqule Corporation and Brandeis University 1996--present As consultant to Arqule Corporation and Visiting Scientist at Brandeis, worked on a joint project between Arqule Corporation and Brandeis on a project involving synthesis of novel protease inhibitors. Designed an enzyme kinetics laboratory; developed, ran, and did troubleshooting of assays to test synthetic inhibitors of thrombin and other inhibitors; performed and presented kinetic analyses of the results. Dana Farber Cancer Institute, Dept. of Cancer Pharmacology 1996--present Under the direction of Dr. Miyako Abe, cultured MCF-7 cells and purified DF3 protein for use in research into the role of DF3 in cellular function. Responsibilities included Labarotory Safety Officer, Radiation Safety Officer, laboratory management, ordering, troubleshooting and maintenance of equipment, conducting experiments. Techniques included cell culture, FPLC, Western immunoblotting, plasmid transfection, and affinity chromatography, PCR, phage library screening, DNA and plasmid purification. Trained and supervised summer student. Tufts University, Dept. of Anatomy and Cell Biology 1995 Held the position of research technician under the direction of Dr. Mary K. Murray. Techniques included lectin chromatography and electrophoresis, DNA cloning, PCR, and DNA sequencing. Massachusetts General Hospital, Dept. of Hematology-Oncology, and Brigham and Women's Hospital, Dept. of Experimental Medicine 1987--1994 Held the position of research technologist under the direction of Dr. Stuart Lind. Responsibilities: Safety Officer, Radiation Safety Officer, lab management, experimental design, conducting experiments, and supervision and training of incoming technician. Techniques included protein purification, affinity and ion exchange chromatography, ELISAs, SDS-PAGE, immunoblots, antibody preparation, small animal surgery, histological staining of rat and human tissue preparations, enzyme kinetics experiments (synthetic substrate assays), fibrinolysis experiments using fibrinogen or whole plasma and I-125, and cell culture. Publications ``Actin Stimulates Plasmin Generation by Tissue and Urokinase-Type Plasminogen Activators,'' by Stuart E. Lind and Carolyn J. Smith. Archives of Biochemistry and Biophysics, vol. 307, no. 1, Nov. 15, 1993. ``Oxidative Inactivation of Plasmin and Other Serine Proteases by Copper and Ascorbate,'' by Stuart E. Lind, Jonathan R. McDonagh, and Carolyn J. Smith. Blood, vol. 82, no. 5, Sept. 1, 1993. ``Actin Accelerates Plasmin Generation by Tissue Plasminogen Activator,'' by Stuart E. Lind and Carolyn J. Smith. Journal of Biological Chemistry, vol. 226, no. 26, Sept. 15, 1991. ``Actin Is a Noncompetitive Plasmin Inhibitor,'' by Stuart E. Lind and Carolyn J. Smith. Journal of Biological Chemistry, vol. 266, no. 8, March 15, 1991. Education Massachusetts Institute of Technology, B.S., Life Sciences, 1987