22.920 Course Syllabus
TA's: Mark Price, Scott Packard, and Sumi Bao
Class 1 Monday, Jan. 6
General introduction to magnetic resonance
Lab 1 Mark Price to organize
- (three groups, use AMX-400, AMX-600, and AMX-122/100)
- all with a water sample
- measure 1D spectrum
- see fid
- on and off resonance
- shimming
Class 2 Tuesday, Jan. 7
Bloch's eqn.
Rotating Reference Frame
RF Pulses
Lab 2 Scott Packard to organize
- (three groups, use AMX-400, AMX-600, and AMX-122/100)
- calibrate 90° and 180° pulses -
show plot of intensity vs pulse length
- off resonance behavior of RF pulses
- Relaxation
- T1, and T2* (decay of FID)
- inversion recovery - show plot of intensity vs delay
class 3 Wednesday, Jan. 8
Magnetic field gradients, k-space diffusion
Lab 3 Sumi Bao to organize
- (three groups, use AMX-400, AMX-600, and AMX-122/100)
- 1-D profile
- gratings
- pseudo echo detection
- diffusive attenuation w/ gradient echo - show plot
class 4 Thursday, Jan. 9
Spin echoes
Hahn Echo
90 - 90 echo
Stimulated echo
Lab 4 Mark Price to organize
- (three groups, use AMX-400, AMX-600, and AMX-122/100)
- Hahn echo
- 90 - 90 echo
- stimulated echo - observe all five echoes
- diffusive attenuation w/Hahn Echo
- Carr-Pucell pulse train
class 5 Monday, Jan. 13
NMR imaging
2D images
slice selection
Lab 5 Scott Packard to organize
- (three groups, use AMX-122, AMX-100, and AMX-200)
- Slice selected gradient echo imaging
- go through entire setup
class 6 Tuesday, Jan. 14
More imaging
Spin echo vs gradient echo
Resolution
Flow
Lab 6 Scott Packard to organize
- (one group, use AMX-200)
- slice selected spin echo imaging
class 7 Wednesday, Jan. 15
Spectroscopy
Chemical shifts
Couplings
Assignments
Lab 7 Mark Price to organize
- (two groups, use AMX-400, and AMX-600)
- 1-D proton spectra of simple compounds
class 8 Thursday, Jan. 16
2D spectroscopy, and the COSY experiment
Lab 8 Sumi Bao to organize
- (two groups, use AMX-400, and AMX-600)
- COSY of simple compounds
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