Department
of Chemistry
Massachusetts
Institute of Technology
Principles of Inorganic Chemistry, Bioinorganic
Chemistry
Chemistry 5.062 Fall Term, First Half, 2004
Professor Stephen J. Lippard Room 18-498; Ext. 3-1892
Course Assistant, Andy Tennyson Room 18-444; Ext. 3-1823
Web site web.mit.edu/5.062/www/
Lectures will be held on Tuesday and Thursday from 8:30-9:55 A.M. in Room 2-132. The specific schedule is given below. Recitation sections run by Prof. Lippard will meet once a week in the Noyes Room (18-478) at a time to be determined. Required text, Lippard and Berg, "Principles of Bioinorganic Chemistry", University Science Books, 1994, second printing, is available in the Tech Coop. It should be purchased before September 10, 2004. Read Chapters 1-6 in L&B and start the problems at the ends of the chapters as your first assignment. Problems are due at the lecture designated in the syllabus below.
|
Lecture |
Date |
Lecture Topic |
Reading |
Problems |
|
1 |
9/9 (Th) |
Intro; Choice, Uptake, Assembly of Mn+ Ions |
Ch. 5 |
Ch. 1 |
|
2 |
9/14 (Tu) |
Metalloregulation of Gene Expression |
Ch. 6 |
Ch. 2 |
|
3 |
9/16 (Th) |
Metallochaperones; Metal Folding, X-linking. |
Ch. 7 |
Ch. 3 |
|
4 |
9/21 (Tu) |
Med. Inorg. Chem./Metalloneurochemistry |
Ch. 8 |
Ch. 4 |
|
5 |
9/23 (Th) |
Mössbauer, EPR, IR Spectral Fundamentals |
Ch. 9 |
Ch. 5 |
|
6 |
9/28 (Tu) |
Electron Transfer; Fundamentals |
Ch. 9 |
Ch. 6 |
|
7 |
9/30 (Th) |
Long-Distance Electron Transfer |
Ch. 10 |
Ch. 7 |
|
8 |
10/5 (Tu) |
Hydrolytic Enzymes, Zinc, Ni, Co |
Ch. 10 |
|
|
9 |
10/7 (Th) |
CO and Bioorganometallic Chemistry |
TBA |
Ch. 8 |
|
10 |
10/12 (Tu) |
Dioxygen Carriers: Hb, Mb, Hc, Hr |
Ch. 11 |
Ch. 9 |
|
11 |
10/14 (Th) |
O2 Activation, Hydroxylation: MMO, ToMO |
Ch. 11 |
Ch. 10 |
|
12 |
10/19 (Tu) |
Model Chemistry for O2 Carriers/Activators |
Ch. 12 |
Ch. 11 |
|
13 |
10/21 (Th) |
Complex Systems: cyt. oxidase; nitrogenase |
Ch. 12 |
Ch. 12 |
|
14 |
TBA |
Term Examination |
|
|
The grade for this course will be determined by a term exam (35%), a written research paper with oral presentation (55%), and problem sets (10%). The oral presentations will be held in research conference style at an all-day symposium at MIT on Saturday, October 30th. Please reserve the date for there are no excused absences. Papers are due October 28th.
Some suggested resource reading:
D. C. Rees, Great Metalloclusters in Enzymology, Annu. Rev. Biochem., 2002, 71, 221-246.
H. Beinert, Bioinorganic Chemistry: A New Field or Discipline? Words, Meaning, and Reality, J. Biol. Chem., 2002, 277, 37967-37972.
S. J. Lippard, The Art of Chemistry, Nature, 2002, 416, 587.
R. Roat-Malone, "Bioinorganic Chemistry, A Short Course," Wiley-Interscience (2002).
R. L. Rawls, Iron-Sulfur Proteins, C&EN, 2000, November 20th issue, p. 43.
Z. Guo and P. J. Sadler, Metals in Medicine, Angew. Chem. Int. Ed., 1999, 38, 1512-1531.
Bioinorganic Chemistry Special Feature, Proc. Natl. Acad. Sci. USA, 2003, 100, 3562-3840.
Radical Enzymology, Chem. Rev., 2003, 103, p. 2081 ff.
Comprehensive Coordination Chemistry II; From Biology to Nanotechnology, J. A. McCleverty and T. J. Meyer, Volume 8 (Que, Tolman, eds.) Elsevier (2004)
For fun:
P. Saltman, J. Gurin, and Ir. Mothner, "The University of California San Diego Nutrition Book," Little Brown and Co., New York, NY.