SP.237: The Artist in the World

Instructor: Graham Ramsay, Bldg 24-604, xt. 8-0481

Spring 2007: Class #11, April 26, 2007

Alice Flaherty , author

 

Biography

 Alice Weaver Flaherty, like so many other artists, has a day job unrelated to her work as an author. What is somewhat more unusual is that her day job is as a respected and accomplished neurologist and practicing MD at Massachusetts General Hospital. Her love of language is often married with her love of science, and she sometimes combines the two, as her book The Midnight Disease: The Drive to Write, Writer's Block, and the Creative Brain. Her work is erudite, poetic, and playful, while at the same time offering insightful and probing looks into the cross-over between brain science and art. She experiments with a broad range of written forms including dramatic libretto and poetry; her most recent endeavor is a book geared to children, The Luck of the Loch Ness Monster: A Tale of Pediatric Food Aversion forthcoming from Houton Miflin.

 

 

 

 

 

 

 

 

Interview:

Interview with Alice Flaherty for Harvard Medical Alumni Bulletin

 

 

Work Samples:

1. Introduction to The Midnight Disease: The Drive to Write, Writer's Block, and the Creative Brain

2. Chapter 4 from The Midnight Disease: The Drive to Write, Writer's Block, and the Creative Brain

 

Cirriculum Vitae

Name: Alice Weaver Flaherty MD, PhD

Office Address: Depart ment of Neurology, VBK915, MGH, Fruit St. , Boston MA 02114

Home Address: 22 Union St. , Cambridge MA 02141

Tel. 617-726-1405 EMail:
aflaherty@partners.org FAX: 617-726-2353

Place of Birth: U.S.A.

Education:

1985 AB, summa cum laude, Harvard College

1985-86 University of Michigan , graduate work in Philosophy

1992 PhD, Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

1994 MD, magna cum laude , Harvard Medical School (HMS)

Postdoctoral Training:

1994-95 Intern, Dept. of Medicine, Massachusetts General Hospital (MGH), Boston , MA .

1995-98 Resident, Dept. of Neurology, MGH

1997-98 Chief Resident, Dept. of Neurology, MGH

1998-00 Movement Disorders Fellow, MGH

Licensure and Certification:

1998 Full license, Massachusetts Board of Registration in Medicine

2000 Board Certification in Neurology

Academic Appointments:

1995-96 Clinical Fellow in Neurology, HMS

1998-04 Instructor in Neurology, HMS

2005- Assistant Professor in Neurology, HMS

Hospital or Affiliated Institution Appointments:

1999- Assistant in Neurology, MGH

1998-99 Graduate Assistant in Neurology, MGH

1998-00 Visiting Scientist, with admitting privileges at the Clinical Research Center , MIT

2001- Consultant, Department of Neurology, McLean Hospital , Belmont , MA

Other Professional Positions and Major Visiting Appointments:

•  Specialty reviewer, Oxford University Press

•  Specialty reviewer, Lippincott, Williams and Wilkins

Hospital and Health Care Organization Service Responsibilities:

1998- Attending Physician, Neurology Service, MGH

•  Neurologist, Movement Disorders Unit, MGH

•  Consulting Neurologist, McLean Hospital

Major Administrative Responsibilities:

2003- Director, Movement Disorders Fellowship

2005- Resident Ombudsman, MGH Neurology

•  Principal neurologist, Functional Neurosurgery for Movement Disorders Committee, MGH

Major Committee Assignments:

1996-97 Neurology Residency Selection Committee, MGH

•  WEB-MED (Web-Enabled, Bi-directional Medical Education Device) Project, HMS

•  Functional Neurosurgery for Movement Disorders Committee, MGH

2001- HST Board of Advisors, MIT

2001- Psychiatric Neurosurgery Committee, MGH

2001-2 Resident as Teacher Program, the Academy at HMS, representative for Neurology

•  Neurology Residency Selection Committee, MGH

•  Subcommittee on Review of Research Proposals, Executive Committee on Research, MGH

•  Psychopharmacology Committee, MGH

Professional Societies:

1988- Society for Neuroscience

1994- Massachusetts Medical Society

1995- American Academy of Neurology

2004- Brain and Behavior Group, HMS and MIT, charter member

Community Service Related to Professional Work:

1990-94 Radcliffe Mentor Program, Harvard University

2002-03 Bio-Matrix Mentor Program, MIT

2002-03 Harvard College Mental Health Advocacy and Awareness Group

Editorial Boards:

•  Nature , ad hoc reviewer

•  P.N.A.S. , ad hoc reviewer

•  Neuroimage, ad hoc reviewer

•  Journal of Neurophysiology, ad hoc reviewer

•  Neurology, ad hoc reviewer

•  Harvard Medical Alumni Bulletin, Board of Editors

Awards and Honors:

1981-85 John Harvard Scholarship, Harvard University

1981-85 Elizabeth Cary Agassiz Scholar, Harvard University

1982 Detur Prize, Harvard University

1985 A.B. granted with highest honors, Harvard College

1994 M.D. granted with high honors, Harvard Medical School

1997 Chief resident, Dept. of Neurology, MGH

1998 The Olcott Fellow, Dept. of Neurology, MGH

1999 The Rappoport Scholar, MGH

2000 Moby Award, Best Educational Application, for the electronic version of the MGH Handbook of Neurology

2002 Partners in Excellence Award, MGH for outstanding performance

2004 Finalist, Schwartz Center Compassionate Caregiver Award (one of 7 finalists statewide)

2005-06 Helen Putnam Fellow, Radcliffe Institute of Advanced Studies (Bunting)

2005 William Saroyan International Writing Prize, nonfiction short list (10 authors)

 

PART II: RESEARCH, TEACHING, AND CLINICAL CONTRIBUTIONS

 

•  Narrative report of Research, Teaching, and Clinical Contributions

My focus is on how basal ganglia disorders interact with disorders of motivation and mood.

Research: I first approached this intersection through electrophysiology of primate movement control. We showed that sensorimotor maps fracture to interdigitate with limbic inputs in the striatum but then recombine in the pallidum. This interaction may underlie distortions in the drive to act, as in Parkinson's disease and drug addiction. My subsequent functional MRI research further supports the striatum's behavioral role. We found left-dominance of movement activation—suggestive, since hemispheric dominance is usually restricted to higher cortical functions. We see greater activation when dystonics imagine performing a task than when they actually perform it. We find dramatic striatal activation early in movement, supporting the controversial striatal role in movement initiation. Now I am also studying how agents affecting motivation, such as dopaminergic drugs, phototherapy, and brain stimulators, affect mood and idea initiation. I am involved in planning a multicenter trial for stimulator treatment of depression.

Teaching and writing: Because of a passion for writing, even in medical school I contributed to several respected textbooks. While still a resident, I wrote the single-authored MGH Handbook of Neurology . It is multiply translated and won a national award. Harvard has funded its expansion into a neurology core curriculum containing video clips, cases, and a lesion localizer. As director of the MGH Movement Disorder Fellowship, I am significantly expanding its clinical breadth. I supervise and lecture students, residents, and fellows in the psychiatry as well as neurology departments. With the Resident as Teacher program, I developed two initiatives to help trainees communicate with patients and other doctors. I work also to teach alexithymic patients to better express their concerns. Patients now often show me memoirs of their illness—studies show such writing improves objective indices of health.

One can sometimes teach general audiences and academic audiences about their brains simultaneously. My second book, The Midnight Disease, researches the neurological basis of the drive to communicate and how we write. It has received excellent reviews and invitations from both scholarly organizations and general publications like The New York Times . My third book, a subversive look at pediatric food aversions, is in press, and my fourth, on adaptationist explanations of illness, is in preparation.

Clinical Work: My inpatient attending on our department's most demanding service (CMF) began only a year after my residency—perhaps a record. I saw more patients last year than any other member of my department, and I saw three times more patients than the Movement Disorder's Unit's average. I head the deep brain stimulator program, a position that requires highly technical programming skills and frequent emergency visits. Because I often see my stimulator patients every two weeks, I get to know them well personally. My patients frequently have serious psychiatric comorbidity—a very underserved population. Last year I was recognized statewide as a Schwartz Compassionate Caregiver finalist. The Midnight Disease has brought me a population of writer and composer patients whose neurological problems affect their art. Finally, I helped found the MGH Neurology Evaluation Clinic to counterbalance neurology's sub-sub-sub-specialization (to which I otherwise contribute).

•  Funding Information

Research:

1998-04 NIH K08 NS02067-01. PI: Flaherty. Basal Ganglia fMRI in Normal and Parkinsonian Patients

1998-99 American Parkinson Disease Association. PI: Flaherty. Basal Ganglia fMRI in Parkinson's Disease

1998-99 The Olcott Endowment. PI: Flaherty. Imaging the Basal Ganglia.

1999-00 The Rappoport Endowment. PI: Flaherty. Functional MRI of Movement Disorders

1999-00 Sir Arthur Weller Fund for the Study of Vibration Therapy in Parkinson's Disease. PI: Flaherty

2003- Lippincott, Williams and Wilkins textbook development fund. PI: Flaherty.

2004- Claflin Distinguished Scholar Award, MGH.

2004- Harvard Center for Neurodegeneration and Repair. PI: Paolo Bonato. Enhancing DBS parameter adjustment through measures of motor response

2005- The John Murphy Fund. PI: Psychosomatic interactions in disease.

2005- Radcliffe Institute for Advanced Study. PI. Adaptationist explanations of disease and denial.

Education:

1999-00 HMS Dean's Clerkship Information Technology Innovation Fund. PI: Lee Schwamm. A Web-Enabled Bidirectional Medical Education Device

•  HMS Dean's Clerkship Information Technology Innovation Fund. PI: Lee Schwamm. A Handheld Electronic School-wide Neurology Clerkship Curriculum.

2002- Resident as Teacher program, developed by Dean Federman.

2003- Harvard University Provost's Fund for Innovation In Instructional Technology. PI: Lee Schwamm.

•  Report of Current Research Activities

1998- Basal ganglia fMRI in Parkinsonians. PI. I scan subjects, analyze data, and write papers.

1999- Effects of brain stimulators in movement disorders. Clinical research with collaborators.

2000- FMRI of dystonic patients. Design experiments, supervise a postdoctoral fellow.

•  Enhancing DBS parameter adjustment through objective measures of motor response. Collaborator.

2002- Biologically-based enhancement of human creativity. PI. Design and supervise experiments.

D. Report of Teaching

1. Local contributions

a. Student courses

•  HMS Third-Year Neurology Clerkship. Inpatient case presentations, 3 students, 1h/d, 1 mo/y.

1999-2001 HMS Patient-Doctor II. Instructor, neurological examination. 3-5 students, 4h contact once a year.

2000- HMS Third-Year Neurology Clerkship. Outpatient teaching, 1 student/wk, 4 h contact, all year.

b. Graduate medical courses

•  MGH Neurology Resident Research Lecture Series, lecturer, 15 residents, 6h prep, 1.5h contact/yr

•  MGH Neurology Resident Clinical Lecture Series, lecturer, 15 residents, 6h prep, 1.5h contact/yr

•  MGH Neurology Mortality and Morbidity, case discussant, 15 residents, 2h contact/yr

•  MGH Psychiatry Resident Teaching Series, invited discussant, 25 residents, 1.5h contact/yr

2006- HMS Neurobiology of Disease course, lecturer, 30 graduate students, 3h contact

c. Local invited teaching presentations

1996 MIT Veterinary Research Series. “Veterinary and human prion diseases.” 12 DVMs, 20h prep, 2h contact.

1997 McLean Psychiatry Resident Didactic Sessions, “Psychiatric aspects of basal ganglia disorders,” 9 residents, 20h prep, 2h contact

1999 Spaulding PMR Resident Didactic Sessions, “Movement disorders and ataxia,” 11 residents/yr, 6h prep, 2h contact

1999 Seminar in Cognitive Theory in the Arts, Harvard University , “Writing as disease,” 40 faculty and grad students, 20 h prep, 2 h contact

1999 Parkinsons' United Patient Support Group, Boston , “Psychiatric aspects of Parkinson's Disease,” 15 patients, 10 h prep, 2 h contact.

1999 Deep Brain Stimulator Support Group, Boston . “Stimulator adjustments,” 30 patients, 10 staff, 2 h contact

2002- present. Cambridge Hospital Psychiatry residency, “Movement disorders in psychiatry,” 6 staff, 6 residents, 5 hours prep

2002-present. MGH-BWH Neurology residency, “Deep brain stimulation,” 20 residents, 4 h prep, 1 h contact.

•  Harvard Mental Health Awareness and Advocacy Group, panel discussion, “Writer's block and procrastination,” 100 students and faculty, 2 hours contact.

2003 Longwood combined BWH-BIDMC Neurology Grand Rounds “The neuroscience of the motivation to write,” 50 residents and staff, 10 h prep, 1 h contact.

2004 MIT Department of Brain and Cognitive Science, “The cognitive neuroscience of Parkinson's disease,” 20 students, 15 h prep, 2h contact (scheduled)

2004 Neurology Grand Rounds, MGH, “(Grant-)Writing as Disease,” 75 staff, 20 h prep, 1 hour contact.

2004 MIT Department of Health Sciences and Technology, “The art and science of medicine: neurology,” 40 students, 10 hours prep, 2 hours contact.

2005 Psychiatry Grand Rounds, MGH “Disorders of Creativity,” 100 staff, 20 hour prep, 1 hour contact.

2005 MGH Neurology Neuroscience Series, ”Neurological Treatment of Psychosomatic Symptoms,” 20 residents, 15 h prep, 1 h contact.

2005 Psychiatry and the Law seminar, Harvard College , “Professional competence,” 15 undergraduates, 2 hours prep, 1 hour contact

2005 Panel discussion on medical student health, HMS, 200 students, 10 hours prep, 2 hours contact.

2006 Hoffman Seminar Series, Psychiatry, Cambridge Hospital , 12 senior staff; 5 two-hour sessions.

2006 Spaulding Hospital , “Deep Brain Stimulation,” 30 medical staff

2006 Seminar leader, “Minds and Machines,” Symposium, Harvard (8 hrs of meetings, 100 listeners)

d. Continuing medical education courses

2000 Conference on Health Care and the Internet, Boston . “Personal digital assistants in medical education.” 200 MDs. 30h prep, 1h contact

2000 Ehealthcareworld, NYC. “PDAs and the Web,” 200 MDs. 20h prep, 1h contact

2001 Baker Educational Symposium, American Academy of Neurology, “An interactive portable neurological tool.” 300 neurologists. 10 h prep, 1 h contact

e. Advisory and supervisory responsibilities in clinical or laboratory setting

1999- Clinic supervisor of students, residents, and fellows, 6h/wk.
2000- Supervising a PhD postdoctoral fellow performing and analyzing fMRIs, 4h/wk.

2003- Research assistants, 2 h/wk

f. Teaching leadership role

•  WEB-MED project to develop a handheld (PDA) electronic neurology textbook.

2001- Board of Advisors, MIT HST Program. Supervise curriculum and students issues.

•  HMS Dean's I.T. Initiative Program to develop an electronic neurology curriculum.

2002-03 Resident as Teacher Committee, HMS. I started two projects to improved residents' writing.

g. Names of advisees or trainees

2000-4 Anne Blood, PhD, research fellow, MGH NMR center

2001-6 Minhaj Siddiqui, medical student, HST program

2001- Zuzana Tothova, medical student, HST program

2002- Felipe Jain, medical student, HST program

2002- Vanessa Henke, medical student, HST program

2002 Anne-Marie Wills, MD, MGH neurology resident; movement disorder fellow

2002-03 Katrin Sadigh, BA, research assistant

2003-4 Wendy Galpern, MD, PhD, MGH movement disorders fellow

2003-4 Alberto Lleo, MD, MGH movement disorders fellow

2003- Hui-Fai Fong, medical student, HST program

2003- Gyanprakash Ketwaroo, medical student, HST program

2003 Adina Gerver , AB , research assistant

2004- Shivraj Sohur , MD , PhD, movement disorders fellow

2004-7 Mee-Ohk Kim, MD, PhD, movement disorders fellow

2004- Yao Liu, medical student, HST program

2004-6 Talene Yacoubian, movement disorders fellow

2005- Sophia Wang, research assistant, Harvard College

2006- Nikolaus MacFarland , MD , PhD, movement disorders fellow

2006- Timmy Ho, medical student, HST program

2. Regional, national, or international contributions

a. Invited presentations

Academic

2000 Conference on Health Care and the Internet, Boston . Lecture. 200 listeners.

2001 American Academy of Neurology Baker Colloquium, Philadelphia . Lecture. 300 listeners.

2001 American Medical Publishers Annual Meeting, Philadelphia . Lecture. 200 listeners.

2003 Brown University Neurology Grand Rounds, Providence . Lecture. 125 listeners.

2003 UCLA Brain Research Institute Tennenbaum Lecture Series. 75 listeners.

2004 International Psychoanalytical Assn. Meeting, New Orleans . Lecture; panel. 75 listeners.

2004 Wellesley University English Department Special Lecture. 150 listeners.

2004 Massachusetts Medical Society Annual Meeting, Keynote Address, Arts Show. 50 listeners

2004 Learning and the Brain Conference, Cambridge , MA . Lecture, 250 listeners.

2004 Manic-Depressive and Depressive Assn. Meeting, McLean Hospital , lecture, 75 listeners.

2005 Drexel University Peer Writing Counselors Workshop, 20 listeners

2005 Drexel University Pacifico Annual Lecture, 200 listeners

2005 Johns Hopkins Neurology Grand Rounds First Annual McKhann Lecture. 100 listeners

2005 Brown University , St. Anthony Hall, literary lecture series, 40 listeners

2005 Massachusetts Medical Society Lecture, 50 listeners

2005 University of Rochester Neurology Grand Rounds , 70 listeners

2005 Interdisciplinary Colloquium on Psychoanalysis & Culture, NYPSI, 15 listeners

2005 Arnold Pfeffer Center at the New York Psychoanalytic Institute, lecture, 200 listeners

2005 International meeting on limbic system anatomy, plenary lecture, the Netherlands , 50 listeners

2005 Bunting lecture, Radcliffe Institute for Advanced Study, Harvard University , 175 listeners

2005 Panelist, Scholars on Writing, Harvard University , 30 listeners

2006 Radcliffe Speaker's Series, New York , 30 listeners

2006 Keynote speaker, Maine Parkinson's Disease Society, 150 listeners

2006 Panelist, Tropes of Trauma in Literature and History, Harvard University , 20 listeners

2006 Discussant, HMS seminar on psychotherapy and the arts, 5 3-hour seminars, 20 members.

2006 Martha's Vineyard Hospital Medical Grand Rounds, 2h, 20 listeners

2007 Philoctetes Society, NYU, panel discussion on the imagination (scheduled)

2007 Symposium on Depression Treatment, Palm Beach (scheduled)

General public

Television appearances:

2004 Dateline NBC episode on The Midnight Disease

2004 ABC news clip on writer's block and depression distributed to member stations

2004 Dedham , MA cable show “Candid Conversations” on Parkinson's disease

2004 New England Cable Network episode on a patient with levodopa-induced musical talent

2005 German Public TV “Schreibblockade” on writer's block

2005 ABC Prime Time clip on a patient with medication-induced creativity

2006 Japanese TV documentary on the neurology of creativity (OfficeKei Productions)

2006 Maine TV news clip on Parkinson's disease

2006 Middle East TV news clip featuring a patient

2006 British Channel 4 Public TV documentary “Painting the Mind” on brain injury and art

2006 BBC Horizon documentary on creative drive (filmed, in production)

2006 CBC documentary based on Lauren Slater's Opening Skinner's Box (filmed, in production)

2007 National Geographic documentary on savants (filmed, in production)

2007 Channel 5 Chronicle clip on mental illness and creativity

Radio interviews:

2004 Morning Edition, with Renee Montagne (national)

2004 with multiple reruns, The Diane Rehm Show (national)

2004 To the Best of Our Knowledge (national)

2004 The Leonard Lopate Show (NYC)

2004 Talk of the City, with Kitty Felde (LA)

2004 The Forum, with Michael Krasny (SF)

2005 with multiple reruns, The Infinite Mind, with Peter Kramer (national)

2005 Writers on Writing, with Barbara de Marco-Barrett (CA)

2005 The 6PR Breakfast Show ( Perth , Australia )

2005 To the Best of Our Knowledge (Wisconsin Public Radio)

2006 Studio 360 (national)

Book talks for general audiences:

2004 Harvard

2004 Berkeley

2004 UCLA

2004 University of Washington

2004 Bainbridge Island Writer's Colony

2004 New England Bookseller's Association

Performance pieces and installations:

2004 Mobius Annual Performance Art Fundraiser, installation with performance, Boston . “Diagnosis,” Flaherty AW, Huckleberry S, Huckleberry J, Johnson N, Marcus R, Phelan V, Vogler A. 200 viewers.

2006 Deval Patrick Political Fundraiser, Boston , “stand-up neuroscience”on “the top 10 ways to seem psychosomatic”, 60 listeners/viewers

2006 Pagan Kennedy, Confessions of a Memory Eater , Boston . “stand-up neuroscience” with the author of a novel about memory, 80 listeners.

2007 Graham Ramsay, composer, AW Flaherty, programmatic verse, “Jacob Wrestling . ” Lyric exploration of the nature of affliction, for an organ work commissioned by Heinrich Christensen). Scandinavian tour planned.

b. Professional and educational leadership role related to teaching

1998- Cofounder of the WEB-MED and Electronic Neurology Curriculum projects, HMS

3. Description of teaching awards received

2000 Moby Award, Best Educational Application, for The MGH Handbook of Neurology's electronic version.

2005 Neurology Resident Mentor Award (co-recipient).

4. Major curriculum offerings, teaching cases or innovative educational programs developed

1997-00. Developed a handbook of neurology used internationally. Multiple foreign translations and an electronic edition are available. Second edition is in preparation.

1998- Collaborative development of a multimodal neurology curriculum including a lesion localizer, and video clip library demonstrating exam findings.

2004- The Midnight Disease is required reading in university courses across the US and Europe .

E. Report of Clinical Activities

1. Description of clinical practice

•  Movement Disorders Unit, MGH: Most of my patients have either brain stimulators or significant comorbid psychiatric illness. Many require frequent emergency stimulator visits. Many are refractory referrals from other tertiary care facilities.

•  CMF Neurology Service, MGH: An MGH inpatient unit serving NICU and other critically ill patients.

•  Inpatient consults, MGH: Patients with medical and surgical issues, as well as movement or neurobehavioral issues

•  Neurology Evaluation Clinic, MGH: general neurology initial referrals, an MGH outpatient clinic.

•  McLean Hospital . Neurology consults on inpatients, chiefly those with major affective disorders or psychosis

2. Patient load

Clinic: 2-3 clinic sessions/wk, ~22 patients/wk.

Attending: Attend on the CMF service 1 month/yr, average 20 patient/day census including about 5 ICU patients

Inpatient consults ~1 patients a month.

3. Clinical contributions

A. I evaluate and oversee all (approximately 40) deep brain stimulator patients treated at MGH.I trained and give daily supervision to the nurse practitioner who assists with these patients. I am the most senior neurologist on the functional neurosurgery for movement disorders committee, and have spearheaded the introduction of brain stimulation to the psychiatric neurosurgery committee. We are planning trials of brain stimulation for depression
B. I am the only neurologist at MGH who focuses on patients with major psychiatric disorders as well as neurological ones. Diagnoses range from bipolar tremor to experimental treatments for tardive dyskinesia, to patients with compulsive gambling or gender identity disorder after stimulator surgery.
C. Because of my work on the neurology of hypergraphia and writer's block, I see a cohort of professional writers and other artists who complain of creative block, often in the context of a neurological problem. When block stems from a medical issue such as organic mood disorder, medication side effects, or the abulia associated with parkinsonism, it can often be treated medically when traditional cognitive-behavioral techniques have failed.

4. Other relevant information about clinical role

1997-98 Chief resident in neurology, MGH

2004 Finalist, Kenneth Schwartz Compassionate Caregiver Award (7 finalists, statewide pool)

2006 Parkinson's Disease Patient Symposium, keynote speaker (planned)

 

PART III: BIBLIOGRAPHY

 

A. Original Articles

•  Godley BF, Flaherty AW, Wurtman RJ. The effects of light on retinal dopamine in the rat. Annals of the New York Academy of Sciences . 1985;453:383-384.

•  Flaherty AW, Graybiel AM. Corticostriatal transformations in the primate somatosensory system: I. Projections from physiologically-mapped body-part representations. J Neurophys 1991;66:1249-1263.

•  Flaherty AW, Graybiel AM. Two input systems for body representations in the primate striatal matrix: experimental evidence in the squirrel monkey. Neurosci 1993;13:1120-1137.

•  Flaherty AW, Graybiel AM. Output organization of the primate putamen. J Neurosci 1993;13:3222-3237.

•  Flaherty AW, Graybiel AM. Input-output organization of the sensorimotor striatum in the squirrel monkey. J Neurosc . 1994;14:599-610.

•  Graybiel AM, Aosaki T, Flaherty AW , Kimura M. The basal ganglia and adaptive motor control. Science 1994;265:1826-1831.

•  Flaherty AW, Graybiel AM. Motor and somatosensory corticostriatal projections magnifications in the squirrel monkey. J Neurophysiol 1995;74:2638-2647.

•  Scholz VH, Flaherty AW, Kraft E, Keltner JR, Kwong KK, Chen YI, Rosen BR, Jenkins BG. Laterality, somatotopy and reproducibility of the basal ganglia and motor cortex during motor tasks. Brain Res 2000;879:204-15.

•  Kraft E, Flaherty AW, Chen A, Kwong KK, Jenkins BG. Laterality and temporal influences on brain activation during sequential finger movement. Neuroimage 2001;13(6): S1205-S1205 Part 2 Suppl. S.

•  Eskandar EN, Flaherty A, Cosgrove GR, Shinobu LA, Barker FG 2nd. Surgery for Parkinson disease in the United States , 1996 to 2000: practice patterns, short-term outcomes, and hospital charges in a nationwide sample. J Neurosurg 2003;99(5):863-71.

•  Blood AJ, Flaherty AW, Choi J, Hochberg FH, Greve DN, Bonmassar G, Rosen BR, Jenkins BG. Basal ganglia activity remains elevated after movement in focal hand dystonia. Ann Neurol 2004;55:5 744-48.

•  Flaherty, AW. Frontotemporal and dopaminergic control of creative drive. J Comparative Neurology 2005;493:147-53 .

•  Flaherty AW, Williams ZM, Amirnovin R, Kasper E, Rauch SL, Cosgrove GR, Eskandar EN. Deep brain stimulation of the anterior internal capsule for the treatment of Tourette syndrome: technical case report. Neurosurgery . 2005 Oct;57(4 Suppl):E403-7; discussion E403.

C. Reviews, Chapters, and Editorials

•  Flaherty, AW. Mirror, mirror…. Science 1989;245(4919): 693-693.

•  Graybiel AM, Flaherty AW, Gimenez-Amaya JM. Striosomes and matrisomes. In Bernardi G, Carpenter MB , Di Chiari G, editors. The Basal Ganglia, III , NY : Plenum Press, 1991.

•  Flaherty AW. Standard laboratory methods. In Beck WS, editor. Hematology , fifth ed. Cambridge , MA : The M.I.T. Press, 1991.

•  Flaherty AW, Graybiel AM. The anatomy of the basal ganglia. In Marsden CD, Fahn S, eds. Movement Disorders, III . Butterworths: London , 1994, pp. 3-28.

•  Flaherty AW. Writing like crazy: a word on the brain. Chronicle of Higher Education 2003;50(13):1-6.

•  Flaherty, AW, Akbarian S, MA Samuels. Movement disorders. In T. A. Stern and J. B. Herman, eds., Psychiatry: Update and Board Preparation, second ed. New York : McGraw Hill 2004.

•  Flaherty, AW, Akbarian S, MA Samuels. Stroke. In T. A. Stern and J. B. Herman, eds., Psychiatry: Update and Board Preparation, second ed. New York : McGraw Hill 2004.

•  Flaherty, AW. Monkey business. The Harvard Medical School Alumni Bulletin , autumn 2004.

•  Flaherty, AW. Just got to write this down. The New Scientist, 29 Oct. 2005:48-49.

•  Flaherty, AW. Bedside manners. The Harvard Medical School Alumni Bulletin , autumn 2005.

•  Flaherty, AW. Anger. The Harvard Medical School Alumni Bulletin , autumn 2006.

•  Flaherty, AW. Movement disorders. In Comprehensive Clinical Psychiatry, Elsevier (in press).

•  Flaherty, AW. Psychosocial effects of deep brain stimulation, or the perils of getting well. Joiurnal Watch Neurology (in press)

D. Books, Monographs, and Textbooks

•  Flaherty AW. The Massachusetts General Hospital Handbook of Neurology . Philadelphia : Lippincott, Williams & Wilkins, 2000.

  1. Spanish translation. ( Neurologia. Madrid : Marban Libros, 2001).
  2. Japanese translation. Tokyo : Medical Sciences International (2001).
  3. CD-ROM edition Philadelphia : Lippincott Williams and Wilkins (2002).
  4. PDA edition. Philadelphia : Lippincott Williams and Wilkins (2003).
  5. Second English edition. (in press).

•  Flaherty AW. The Midnight Disease: The Drive to Write, Writer's Block, and the Creative Brain . Boston : Houghton Mifflin, 2004.

•  German trans., K. Fleckenstein. ( Die Mitternachtskrankheit - Warum Schriftsteller schreiben müssen. Schreibzwang - Schreibrausch - Schreibblockade und das kreative Gehirn. Berlin : Autorenhaus, 2004) .

•  Paperback edition (2005) .

•  Japanese trans., Toshiko Yoshida. ( ?????? Tokyo : Random House-Kodansha, 2006) .

•  Korean translation (in press) .

•  Flaherty AW. The Luck of the Loch Ness Monster: A Tale of Pediatric Food Aversion. Boston : Houghton Mifflin (in press).

E. Thesis

•  Flaherty AW. Multiple stages of sensorimotor processing in the primate basal ganglia. MIT, 1992.

•  Flaherty AW. Contributions of motor and somatosensory cortex to movement control in the primate striatum. HMS, 1994.

F. Nonprint Materials.

•  Flaherty AW. CD-ROM edition of The Massachusetts General Hospital Handbook of Neurology . Lippincott, Williams and Wilkins, 2002.

•  Flaherty AW. PDA edition of The Massachusetts General Hospital Handbook of Neurology . Lippincott, Williams and Wilkins, 2002.

G. Recent Abstracts

•  Flaherty AW, Lester J, Prady S, Schwamm LS. An interactive portable neurological tool. American Academy of Neurology Annual Meeting, Philadelphia , PA , 2001.

•  Kraft E, Flaherty AW, Chen A, Kwong KK, Jenkins BG. Laterality and temporal influences on brain activation during sequential finger movement. Human Brain Mapping Annual Meeting, Bristol , UK , 2001.

•  Blood AJ, Choi J, Flaherty AW, Bonmassar G, Hochberg F, Greenberg SA, Rosen BR, Young AB, Jenkins BG. Motor activity differences between imagined finger movements in normal controls and patients with focal hand dystonia. Human Brain Mapping Annual Meeting, Sendai , Japan , 2002.

•  Flaherty AW, Eskandar EN, Williams ZM, Cebula CC, Cosgrove GR. Novel mood, creativity, and tic control after anterior internal capsule and nucleus accumbens DBS for Tourette Syndrome. NIH Deep Brain Stimulation Consortium Meeting, Washington DC , 2003.

•  Flaherty AW. Mood and creative state influences on temporal perception. International Psychoanalytical Association Biannual Meeting, New Orleans , LA , 2004.

•  Flaherty AW, Eskandar EN, Williams ZM, Cebula CC, Cosgrove GR. DBS control of tics, mood, and creativity in Tourette Syndrome: Sixteen-month follow-up of internal capsule/accumbens stimulation. American Academy of Neurology Annual Meeting, San Francisco , CA 2004.

•  Koss AM, Tramo MJ, Flaherty AW, Young AB. Effect of Auditory Stimulation with Popular Music on Visuomotor Integration and Gait in Parkinson' s Disease. American Academy of Neurology Annual Meeting, 2006

•  Flaherty AW, Carson, S, Williams ZM, Amirnovin R, Rauch SL, Cosgrove GR, Eskandar EN. Effects on tics, mood, and productivity during anterior internal capsule stimulation. Tourette Syndrome Association Meeting, Stresa , Italy 2006.

H. Book Reviews and Interviews:

International

New York Times Book Review, 1/11/04

Toronto Globe and Mail, review, 2/28/03

Valor ( Brazil ), interview and review, 3/04

Associated Press, review, 3/04

Manchester Guardian, review and interview 3/18/04

American Journal of Psychiatry , review, 10/04

PLOS Biology, review, 2(2):e47, 2/17/04

Die Welt ( Germany ), review, 11/13/04

Você S/A ( Brazil ), interview, 2004

Neue Zürcher Zeitung ( Switzerland ), review, 2/19/05

BBC online, review, 4/22/05

Journal of the American Psychoanalytic Association, review, 6/05

De Volkskrant ( Netherlands ), interview, 5/28/05

Perspectives in Biology and Medicine, review, winter 2005

National

Publishers Weekly, review, 11/10/03

Booklist, review, 11/15/03

Chronicle of Higher Education, first serial, 12/03

Washington Post, review, 1/23/04

Harvard Magazine, interview, 1/04

U.S. News and World Report, interview, 2/9/04

Library Journal, review, 3/1/04

Neurology Today, review, 3/04

ScienCentral online 3/9/04

Identitytheory.com, interview, posted 3/10/04

Harvard Medical School Alumni Bulletin, interview 3/04

Commentary, review, 4/04

The New Yorker, 6/14/04

National Geographic, interview, 3/05

ABC PrimeTime online, interview, 6/30/05

Radcliffe Quarterly, interview, spring 2006

Self, interview, 2007 (in production)

Regional

Boston Globe, interview, 12/16/03

Milwaukee Journal Sentinel, reprint of Globe interview, 1/3/04

Village Voice, interview/review, 1/14/04

San Francisco Chronicle, review, 1/18/04

SF Weekly, review, 1/28/04

Seattle Post-Intelligencer, review 1/30/04

Palo Alto Weekly, 2/4/04

Newsday, review 3/21/04

San Francisco Chronicle, Editor's Pick, 2/1/04 and 2/8/04

Miami Herald, reprint of Washington Post review, 2/8/04

Boston Globe, Sunday review 2/7/04

Denver Rocky Mountain News, review, 2/21/04

Newark Star-Ledger, review, 3/31/04

Boston Globe, review, 4/13/04

Chicago Tribune, review, 5/9/2004

Boston Magazine, “Smart Boston ,” 10/06

 

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