HST584/22.561 Magnetic Resonance - Analytical, Biochemical, and Imaging Techniques

Instructors: Bruce Rosen and David Tuch
TA: Mark Khachaturian

Course Syllabus

Course Description
This spring term course is designed for graduate (or advanced undergraduate) students and research scientists with an interest in how nuclear magnetic resonance (NMR) techniques can be used to provide information of value to biological scientists and physicians. The course will introduce basic NMR theory, including spectroscopic and relaxation phenomena. Examples of biochemical data obtained using NMR will be summarized, along with other, related experiments. The course will then focus on imaging with NMR, and include discussion of basic cross-sectional image reconstruction, image contrast, flow and real time imaging, and microscopy.

Course Requirements
2 one hour examinations - 20% each
Weekly problem sets - 50%
Class presentation - 10%

Reading
Lecture notes, journal articles and book chapters will be handed out in class to supplement the class lectures.

Syllabus
Week 1 - Introduction to NMR
Week 2 - Relaxation Mechanisms
Week 3 - Basic NMR Spectroscopy
Week 4 - Introduction to Imaging
Week 5 - NMR Imaging Methods
Week 6 - First Exam / More NMR Imaging
Week 7 - Biological Spectroscopy
Week 8 - Signal Processing in MRI and MRS
Week 9 - Chemical Shift Imaging and Flow Imaging Techniques
Week 10 - Real-time NMR Imaging
Week 11 - NMR Microscopy
Week 12 - Second Exam / Other Advanced Imaging Methods
Week 13 - NMR Images
Week 14 - Class Presentations

Problem Sets