5.54/7.540/20.554 Frontiers in Chemical Biology
Fall 2010
Instructor: Barbara Imperiali
TAs: Michelle Chang, Vinita Lukose
Lecture: MW10.30-12.30 (56-154)
Subject Description:
Introduction to current research at the interface of chemistry, biology, and bioengineering. Topics include nucleic acid and protein synthesis and semisynthesis; selective labeling of proteins and bioorthogonal reactions; mechanisms of DNA damage; RNA structure and function; enzyme catalyzed protein modification and the elaboration of the proteome; methods for analyzing signaling network dynamics; metabolic pathway engineering and metabolomics; small molecules from tools to therapeutics; chemical biology approaches to infectious disease and the immune system. Lectures are interspersed with class discussions and student presentations based on current literature.
Note: This is a graduate level class. Students enrolling in the class must have a strong background in biochemistry, organic chemistry and basic cell biology.
Announcements
Notices for Frontiers class
The short talk slides for Wednesday (Nov 10) are now posted.
Also, under syllabus and assignments you can find 3 examples of good proposals from the 2009 Frontiers class.
BI
Announced on 08 November 2010 3:53 p.m. by Barbara Imperiali
Frontiers Class - Short talk slides for Today Nov 8th now posted
Announced on 08 November 2010 7:48 a.m. by Barbara Imperiali
Class notes Nov 8
I just posted a handout for class tomorrow (Monday). We will first finish up the material on membrane proteins (handouts from last week) and then move on to this new material and the short talk. The short talk slides will be posted later today.
See you all in class!
BI
Announced on 07 November 2010 1:18 p.m. by Barbara Imperiali
Class on Nov 1 -
the reading for Monday's class (with Prof. Hidde Ploegh) is now posted. There are two reviews that overlap a bit, but we posted them both becausde you may prefer one or the other. In addition there is a short communication. Hopefully this will not be too much to take a look at while you are all finishing the review assignment!
In honor of the first big assignment being done and since we are at the half way mark of the semester - there will be coffee, tea and muffins (or something with a high carbohydrate content :-) at class on Monday. So make sure to come in time to stake your claim on that and also to enjoy the next faculty talk.
BI
Announced on 29 October 2010 12:30 p.m. by Barbara Imperiali
Week of October 25th
Reading for the two faculty talks is now posted.
For the Sauer/Baker talk, the Prof. have provided a copy of a not yet published review, so it is not in the typeset format. I have parsed the document into 3 chunks (MS text, Figs and Refs) to make it easier to handle.
The review are due on Nov 1st. Please pay attention to the instruction and include the word length in a line at the beginning of the document. It is important to follow the guidelines! Also please submit 4 copies (all in color if you have color figs), to me in class or in the box outside my office (18-590). I prefer not to get electronic submissions as it all gets a bit crazy with 30 review areticles all coming in at once!!
See you all on Monday!
BI
Announced on 22 October 2010 4:01 p.m. by Barbara Imperiali
