- Image credit: Portion of in-house printed microRNA microarray, part of a microRNA mechanism study performed by Noam Shomron, Burge lab, MIT Biology.
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The materials and information for this class can be found on Stellar. | |
Course Description
Academic Year 2007-08: Fall 2007
Introduction to mathematical modeling techniques to address key questions in modern biology. Overview of modeling techniques in molecular biology and genetics, cell biology and developmental biology. Description of key experiments that validate mathematical models.
Topics include:
- molecular systems biology – constructing and modeling of genetic networks, control theory and genetic networks, lambda phage as a genetic switch, synthetic genetic switches, bacterial chemotaxis, genetic oscillators, and circadian rhythms;
- cellular systems biology – reaction diffusion equations, local activation and global inhibition models, gradient sensing systems, and center-finding networks;
- developmental systems biology – general pattern formation models, modeling cell-cell communication, quorum sensing, and models for Drosophila development.
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