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Searched for: "20.375" Subjects offered any term 1 subject found.
20.375 Applied Developmental Biology and Tissue Engineering
(
)
(Subject meets with 20.475)
Prereq: (7.06, 20.320, and (7.02 or 20.109)) or permission of instructor
Units: 3-0-9
Addresses the integration of engineering and biology design principles to create human tissues and organs for regenerative medicine to drug development. Provides an overview of embryogenesis, how morphogenic phenomena are governed by biochemical and biophysical cues. Analyzes in vitro generation of human brain, gut, and other organoids from stem cells. Studies the roles of biomaterials and microreactors in improving organoid formation and function; organoid use in modeling disease and physiology in vitro; and engineering and biological principles of reconstructing tissues and organs from postnatal donor cells using biomaterials scaffolds and bioreactors. Includes select applications, such as liver disease, brain disorders, and others. Students taking graduate version complete additional assignments.
L. Boyer, L. Griffith
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