6.047/6.878 Computational Biology: Genomes, Networks, Evolution
Fall 2012
Instructor: Manolis Kellis
TA: Rachel Sima Sealfon
Lecture: TR9.30-11 (4-159)
Information:
Covers the algorithmic and machine learning foundations of computational biology combining theory with practice. We cover both foundational topics in computational biology, and current research frontiers. We study fundamental techniques, recent advances in the field, and work directly with current large-scale biological datasets.
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Genomes:
Biological sequence analysis, hidden Markov models, gene finding, comparative genomics, RNA structure, sequence alignment, hashing
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Networks:
Gene expression, clustering/classification, EM/Gibbs sampling, motifs, Bayesian networks, microRNAs, regulatory genomics, epigenomics
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Evolution:
Gene/species trees, phylogenomics, coalescent, personal genomics, population genomics, human ancestry, recent selection, disease mapping
In addition to the technical material in the course, the
term project provides practical experience: (1)
writing an NIH-style research proposal, (2)
reviewing peer proposals, (3) planning and
carrying out independent research, (4)
presenting research results orally in a conference
setting, and (5) writing results in a
journal-style scientific paper. You will work on a project of your
choice with regular feedback and advice from a mentor, your peers,
and the teaching staff.
Announcements
no classes on Friday 9/21--mentoring session and recitation rescheduled
Since this Friday (9/21) is a student
holiday, we're rescheduling the mentoring session and the
recitation.
1. The mentoring session is moved to Monday 9/24 from 4:30pm-5:30pm
in 32D-507.
2. Instead of Friday's recitation, I'll hold an extra
office hours on Sunday 9/23 from 6-8 pm in the couches area next to
32-D507, in case you have questions about the material or problem
set.
Announced on 19 September 2012 10:27 a.m. by Rachel Sima Sealfon
New recitation time, TA office hours, other announcements
will now be held in room 56-114. Recitation # 2 will be held this Friday, 9/14.
2. Next week's office hours are moved to Wednesday (9/19), 6-8pm, couches
area outside 32D-507. In general, office hours are on Mondays, 6-8pm, couches area outside 32D-507.
3. You should have gotten these announcements by email yesterday. If not, email me and I will add you to the mailing list.
4. If you are a cross-registered student, you will need to get an
Athena account for the scribing assignment. Instructions for Harvard
students are here:
http://web.mit.edu/registrar/
5. If you don't have access to the restricted-use portions of the
Stellar site (e.g. the course textbook), email me and I will add you
to the Stellar list.
6. Please provide your feedback on lectures here:
https://docs.google.com/
Announced on 12 September 2012 10:12 a.m. by Rachel Sima Sealfon
