6.047/6.878 Computational Biology: Genomes, Networks, Evolution, Health
Fall 2018
Instructor: Manolis Kellis
TAs: Khoi Thien Nguyen, Taylor J Herr, Anna Sappington, Maxim Y Wolf
Lecture: TR1-2.30 (32-141)
Information:
Covers the computational foundations and research frontiers of computational biology. Advanced algorithmic techniques for rapid genome analysis and interpretation, data integration, epigenomics, comparative genomics, regulatory genomics, single-cell biology, deep learning, bayesian networks, pattern finding, and dissecting diseaes mechanisms.
Genomes: Biological sequence analysis, hidden Markov models, gene finding, comparative genomics, RNA structure, sequence alignment, hashing.
Networks: Gene expression, clustering/classification, EM/Gibbs sampling, motifs, Bayesian networks, Deep Learning, Epigenomics, Single-cell Genomics.
Evolution: Gene/species trees, phylogenomics, coalescent, personal genomics, population genomics, human ancestry, recent selection, disease mapping.
Health: Genetic association mapping, common/rare variants, GWAS, PheWAS, multi-trait mapping, causality/mediation, EHR mining, cancer genomics, CRISPR.
In addition to the technical material in the course, the term project provides practical experience (1) writing an NIH-style research proposal, (2) reviewing peer proposals, (3) planning and carrying out independent research, (4) presenting research results orally in a conference setting, and (5) writing results in a journal-style scientific paper.
Announcements
Grades are all in Gradebook Module
Dear all,All the project grades, pset grades, quiz grades, and final grades are also entered in the gradebook module.
Thanks,
Manolis, Khoi, Taylor
Announced on 14 December 2018 1:34 p.m. by Manolis Kellis
Class projects + Grades posted + Course Evaluation reminder
Dear all,1. Your projects were truly outstanding this year. We were quite blown away by the quality and depth and diversity of the projects. Congrats to all!
2. Grades were just posted on the MIT registrar office. You should be able to see your grades immediately.
3. Please remember to fill out the end-of-term class evaluation survey. I see that 28 of you have already done so, thanks! For the rest of you, please take a moment to fill it out here: https://edu-apps.mit.edu/subjeval/studenthome.htm
Thank you all, it was a true pleasure teaching this class!
Manolis, Taylor, and Khoi
Announced on 14 December 2018 12:59 p.m. by Manolis Kellis
Final presentations slides posted
Dear all,Looking forward to your presentations today! The projects and slides look outstanding. Congrats to all for accomplishing so much already! Looking forward to seeing the fruits of your labors. You can find the collated slides here:
https://stellar.mit.edu/S/course/6/fa18/6.047/courseMaterial/topics/topic2/lectureNotes/Lecture25_FinalPresentations_8up/Lecture25_FinalPresentations_8up.pdf
See you at 1pm! Please make an effort to attend as many of the presentations as possible today. Thanks!
Announced on 11 December 2018 12:43 p.m. by Manolis Kellis
Presentations tomorrow
Please submit your final presentation slides by tomorrow 9am.We will be downloading those slides and compiling them into a central document (PDF) that we'll project during the presentations, to help keep things moving. So please submit your slides on time tomorrow, and double-check that your presentation time works for you!
Presentation signup sheet here if you need it: https://docs.google.com/spreadsheets/d/1HjtORTEzX3SjhcEK8oV7M7IIPLe7b3ogtEX8pHAxqnw/edit
Announced on 10 December 2018 12:24 p.m. by Khoi Thien Nguyen
No recitation today 12/7
Good luck on your projects!If you need tips on your presentation, check out the online resources on the Comm Lab websites.
Let us know if you have any other last minute questions or concerns.
Announced on 07 December 2018 1:25 p.m. by Khoi Thien Nguyen
