Blood Pressure in Rabbits

Description

Five rabbits were studied on two occasions, after treatment with saline (control) and after treatment with the 5-HT_3 antagonist MDL 72222. After each treatment ascending doses of phenylbiguanide were injected intravenously at 10 minute intervals and the responses of mean blood pressure measured. The goal was to test whether the cardiogenic chemoreflex elicited by phenylbiguanide depends on the activation of 5-HT_3 receptors.

Usage

data(Rabbit)

Format

This data frame contains 60 rows and the following variables:

BPchange

change in blood pressure relative to the start of the experiment

Dose

dose of Phenylbiguanide in micrograms

Run

label of run ("C1" to "C5", then "M1" to "M5")

Treatment

placebo or the 5-HT_3 antagonist MDL 72222

Animal

label of animal used ("R1" to "R5")

Source

J. Ludbrook (1994) Repeated measurements and multiple comparisons in cardiovascular research. Cardiovascular Research 28, 303–311.
[The numerical data are not in the paper but were supplied by Professor Ludbrook]

References

Venables, W. N. and Ripley, B. D. (2002) Modern Applied Statistics with S. Fourth edition. Springer.