/* $Id: posit.h,v 6.23 2001/08/29 19:05:03 madden Exp $ * =========================================================================== * * PUBLIC DOMAIN NOTICE * National Center for Biotechnology Information * * This software/database is a "United States Government Work" under the * terms of the United States Copyright Act. It was written as part of * the author's official duties as a United States Government employee and * thus cannot be copyrighted. This software/database is freely available * to the public for use. The National Library of Medicine and the U.S. * Government have not placed any restriction on its use or reproduction. * * Although all reasonable efforts have been taken to ensure the accuracy * and reliability of the software and data, the NLM and the U.S. * Government do not and cannot warrant the performance or results that * may be obtained by using this software or data. The NLM and the U.S. * Government disclaim all warranties, express or implied, including * warranties of performance, merchantability or fitness for any particular * purpose. * * Please cite the author in any work or product based on this material. * * =========================================================================== */ /***************************************************************************** File name: posit.h Author: Alejandro Schaffer Contents: header file for position-based BLAST. $Revision: 6.23 $ *****************************************************************************/ /* * $Log: posit.h,v $ * Revision 6.23 2001/08/29 19:05:03 madden * added parameter posComputationCalled in outputPosComputation * * Revision 6.22 2001/04/03 19:38:24 madden * Changed IDENTITY_PERCENTAGE to 0.94, Added to output of -Q option in outputPosMatrix * * Revision 6.21 2001/01/03 01:49:38 bauer * Changed from static to "LIBCALL": * posAllocateMemory * posPurgeMatches * posCancel * posComputeExtents * posComputeSequenceWeights * posCheckWeights * posComputePseudoFreqs * posScaling * * Revision 6.20 2000/12/29 00:39:00 hurwitz * added ints for freeing of posSearchItems * * Revision 6.19 2000/11/13 14:00:39 madden * Added frequency ratios for * in all standard matrices * * Revision 6.18 2000/11/09 14:27:52 madden * psi-blast fixes for star character * * Revision 6.17 2000/10/10 21:46:31 shavirin * Added support for BLOSUM50, BLOSUM90, PAM250 with -t T * Changed frequency ratio for X from 0.707 to 0.750 to ensure that * score is always -1. * * Revision 6.16 2000/07/31 16:41:02 shavirin * Reduced POSIT_SCALE_FACTOR from 1000 to 200 to avoid overflow * with BLOSUM80; moved declaration os POSIT_SCALE_FACTOR to posit.h * * Revision 6.15 2000/07/25 18:12:04 shavirin * WARNING: This is no-turning-back changed related to S&W Blast from * Alejandro Schaffer * * Revision 6.14 2000/07/07 21:20:08 vakatov * Get all "#include" out of the 'extern "C" { }' scope! * * Revision 6.13 2000/04/29 21:49:05 kans * removed bad characters on Mac * * Revision 6.12 1999/11/15 21:47:00 shavirin * Added parameter Boolean use_best_align into compactSearchItems structure * * Revision 6.11 1999/10/21 16:15:04 shavirin * Removed unused array and all references to array threshSequences * * Revision 6.10 1999/09/03 17:23:48 madden * Eliminated use of posMaxThresh field in posSearchItems * * Revision 6.9 1999/08/04 13:27:11 madden * Added -B option * * Revision 6.8 1999/03/21 19:40:30 madden * Added 3rd argument matrixfp to definition of outputPosMatrix * * Revision 6.7 1999/03/17 16:49:11 madden * Removed comment within comment * * Revision 6.6 1999/01/26 18:27:58 madden * Made functions public for AS * * Revision 6.5 1998/09/28 12:31:32 madden * Used BlastConstructErrorMessage * * Revision 6.3 1998/04/24 19:29:50 madden * Added ideal values to compactSearch * * Revision 6.2 1998/03/25 22:36:19 egorov * Change type of posRepeatSequences * * Revision 6.1 1997/12/23 21:07:08 madden * Changes for checkpointing * * Revision 6.0 1997/08/25 18:53:52 madden * Revision changed to 6.0 * * Revision 1.11 1997/08/11 15:45:28 madden * eliminated obsolete fields * * Revision 1.10 1997/06/25 14:04:51 madden * prototype change * * Revision 1.9 1997/05/29 20:36:23 madden * Add Boolean *posUseSequences * * Revision 1.8 1997/05/22 21:25:30 madden * fixed memory leaks * * Revision 1.7 1997/05/16 20:10:10 madden * Added BLAST_Score **posPrivateMatrix * * Revision 1.6 1997/05/01 15:53:27 madden * Addition of extra KarlinBlk's for psi-blast * * Revision 1.5 1997/04/22 16:36:49 madden * Changes for use of psi-blast with www. * * Revision 1.4 1997/04/10 19:25:53 madden * COMMAND_LINE replaced by ALL_ROUNDS, Char to Int1. * * Revision 1.3 1997/04/09 20:01:53 madden * Functions CposComputation and WposComputation replace posComputations. * * Revision 1.2 1997/04/04 20:44:55 madden * Changed posComputation to return Int4Ptr *. * * Revision 1.1 1997/02/13 15:22:13 madden * Initial revision * */ #ifndef __POSIT__ #define __POSIT__ #include #include #include #include #ifdef __cplusplus extern "C" { #endif #define charsPerLine 20 /*Number of characters of a sequence to print per line for score matrix*/ #define ALIGN_LINE_LENGTH 8192 #define ALIGN_CHARS_PER_LINE 70 #define UNUSED (-1) #define Xchar 21 /*character for low-complexity columns*/ #define StarChar 25 /*character for stop codons*/ #define ALL_ROUNDS 1 /*do all rounds without interruption*/ /* Front-ends to retrieve numbers. */ #define getCkptNlm_FloatHi(d, ckptFile) (getCkptNumber(&(d),sizeof(Nlm_FloatHi),ckptFile)) #define getCkptInt4(i, ckptFile) (getCkptNumber(&(i),sizeof(Int4),ckptFile)) #define getCkptChar(c, ckptFile) (getCkptNumber(&(c),sizeof(Char),ckptFile)) typedef struct posDesc { Int1 letter; /*what is the preferred letter here*/ Boolean used; /*is there any letter here */ Nlm_FloatHi e_value; /*score of highest hsp including this position */ Int4 leftExtent; /*How far left do same sequences match?*/ Int4 rightExtent; /*How far right do same sequences match?*/ } posDesc; typedef struct posSearchItems { Int4 *posCount; /*count of how many sequences match at each query position, default value is 1 to include query*/ Int4 **posC; /*position-sepcific occurrence counts*/ Nlm_FloatHi **posMatchWeights; BLAST_Score **posMatrix; BLAST_Score **posPrivateMatrix; Nlm_FloatHi **posFreqs; Nlm_FloatHi *posGaplessColumnWeights; Int4 posNumSequences; Int4 posResultsCounter; Int4 *posResultSequences; Nlm_FloatHi *posA; Nlm_FloatHi *posRowSigma; Int4 posDescMatrixLength; /* Length of posDescMatrix, for deallocation. */ posDesc **posDescMatrix; posDesc *posExtents; Nlm_FloatHi *posSigma; Int4 *posIntervalSizes; /*interval size used for this column*/ Int2Ptr posRepeatSequences; Boolean *posUseSequences; Nlm_FloatHi *posInformation; Int4 QuerySize; Int4 NumSequences; } posSearchItems; typedef struct compactSearchItems { Uint1Ptr query; Int4 qlength; Boolean gapped_calculation; Int4 alphabetSize; Int4 pseudoCountConst; Nlm_FloatHi ethresh; Nlm_FloatHi lambda; Nlm_FloatHi *standardProb; Int4Ptr *matrix; Char standardMatrixName[50]; BLAST_KarlinBlkPtr *kbp_std, *kbp_psi, *kbp_gap_std, *kbp_gap_psi; Nlm_FloatHi lambda_ideal, K_ideal; Boolean use_best_align; } compactSearchItems; void LIBCALL outputPosMatrix PROTO((posSearchItems *posSearch, compactSearchItems * compactSearch, FILE *matrixfp, Boolean posComputationCalled)); Int4Ptr * LIBCALL CposComputation PROTO((posSearchItems *posSearch, BlastSearchBlkPtr search, compactSearchItems * compactSearch, SeqAlignPtr listOfSeqAligns, Char *ckptFileName, Boolean patternSearchStart, ValNodePtr * error_return, Nlm_FloatHi weightExponent)); Int4Ptr * LIBCALL WposComputation PROTO((compactSearchItems *compactSearch, SeqAlignPtr listOfSeqAligns, Nlm_FloatHi **posFreqs)); Int4Ptr * LIBCALL BposComputation PROTO((posSearchItems *posSearch, BlastSearchBlkPtr search, compactSearchItems * compactSearch, Char *ckptFileName, Char *takeCkptFileName, ValNodePtr * error_return)); void LIBCALL posPrintInformation PROTO((posSearchItems *posSearch, BlastSearchBlkPtr search, Int4 passNum)); void LIBCALL posInitializeInformation PROTO((posSearchItems *posSearch, BlastSearchBlkPtr search)); void LIBCALL posFreeInformation PROTO((posSearchItems *posSearch)); void LIBCALL posConvergenceTest PROTO((posSearchItems *posSearch, BlastSearchBlkPtr search, SeqAlignPtr listOfSeqAligns, Int4 thisPassNum)); void LIBCALL posCancel(posSearchItems *posSearch, compactSearchItems * compactSearch, Int4 first, Int4 second, Int4 matchStart, Int4 intervalLength); void LIBCALL posPurgeMatches(posSearchItems *posSearch, compactSearchItems * compactSearch); /*Cleanup position-specific data structures after one pass*/ void LIBCALL posCleanup PROTO((posSearchItems *posSearch, compactSearchItems * compactSearch)); void LIBCALL copySearchItems(compactSearchItems * compactSearch, BlastSearchBlkPtr search, Char * matrixName); compactSearchItems * LIBCALL compactSearchNew(compactSearchItems * compactSearch); void LIBCALL compactSearchDestruct(compactSearchItems * compactSearch); Boolean LIBCALL posTakeCheckpoint(posSearchItems * posSearch, compactSearchItems * compactSearch, CharPtr fileName, ValNodePtr * error_return); Boolean LIBCALL posReadCheckpoint(posSearchItems * posSearch, compactSearchItems * compactSearch, CharPtr fileName, ValNodePtr * error_return); void LIBCALL posAllocateMemory(posSearchItems * posSearch, Int4 alphabetSize, Int4 querySize, Int4 numSequences); void LIBCALL posCheckpointFreeMemory(posSearchItems *posSearch, Int4 querySize); void LIBCALL posComputeExtents(posSearchItems *posSearch, compactSearchItems * compactSearch); void LIBCALL posComputeSequenceWeights(posSearchItems *posSearch, compactSearchItems * compactSearch, Nlm_FloatHi weightExponent); void LIBCALL posCheckWeights(posSearchItems *posSearch, compactSearchItems * compactSearch); void LIBCALL posFreqsToMatrix(posSearchItems *posSearch, compactSearchItems * compactSearch, Nlm_FloatHi **standardFreqRatios, Int4 multiplier); Uint1 LIBCALL ResToInt(Char input); void LIBCALL getCkptFreqMatrix (Nlm_FloatHi ** theMatrix, Int4 length, Int4 width, FILE * ckptFile); void LIBCALL getCkptNumber(void * numberPtr, Int4 numberSize, FILE * ckptFile ); void LIBCALL copyPosFreqs(Nlm_FloatHi **posFreqsFrom, Nlm_FloatHi **posFreqsTo, Int4 qlength, Int4 alphabetSize); Nlm_FloatHi ** LIBCALL allocatePosFreqs(Int4 length, Int4 alphabetSize); Nlm_FloatHi ** LIBCALL posComputePseudoFreqs(posSearchItems *posSearch, compactSearchItems * compactSearch, Boolean Cpos); void LIBCALL posScaling(posSearchItems *posSearch, compactSearchItems * compactSearch); #define PROTEIN_ALPHABET 26 #define POSIT_SCALE_FACTOR 200 /*underlying Amino Acid frequecies for specific score matrices according to Jorja Henikoff for BLOSUMs*/ static Nlm_FloatHi BLOSUM45_FREQUENCIES[PROTEIN_ALPHABET] = { 0.000, 0.078, 0.000, 0.024, 0.050, 0.058, 0.046, 0.075, 0.025, 0.062, 0.060, 0.094, 0.025, 0.042, 0.043, 0.036, 0.052, 0.061, 0.052, 0.070, 0.013, 0.000, 0.034, 0.000, 0.000, 0.000}; static Nlm_FloatHi BLOSUM62_FREQUENCIES[PROTEIN_ALPHABET] = { 0.000, 0.07422, 0.000, 0.02469, 0.05363, 0.05431, 0.04742, 0.07415, 0.02621, 0.06792, 0.05816, 0.09891, 0.02499, 0.04465, 0.03854, 0.03426, 0.05161, 0.05723, 0.05089, 0.07292, 0.01303, 0.000, 0.03228, 0.000, 0.000, 0.000}; static Nlm_FloatHi BLOSUM80_FREQUENCIES[PROTEIN_ALPHABET] = { 0.000, 0.073, 0.000, 0.029, 0.054, 0.055, 0.047, 0.077, 0.025, 0.067, 0.055, 0.100, 0.024, 0.043, 0.038, 0.034, 0.050, 0.057, 0.050, 0.073, 0.014, 0.000, 0.035, 0.000, 0.000, 0.000}; /*underlying frequency ratios for BLOSUM62 as determined by Stephen Altschul; Stephen and Jorja Henikoff used different number for B,Z,X*/ static Nlm_FloatHi BLOSUM62_FREQRATIOS[PROTEIN_ALPHABET][PROTEIN_ALPHABET] = { {0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.250}, {0.000, 3.903, 0.565, 0.868, 0.545, 0.741, 0.465, 1.057, 0.569, 0.632, 0.775, 0.602, 0.723, 0.588, 0.754, 0.757, 0.613, 1.472, 0.984, 0.936, 0.416, 0.750, 0.543, 0.747, 0.000, 0.250}, {0.000, 0.565, 4.438, 0.345, 4.743, 1.335, 0.324, 0.739, 0.925, 0.334, 0.855, 0.297, 0.405, 4.071, 0.554, 0.944, 0.703, 1.058, 0.826, 0.351, 0.253, 0.750, 0.409, 1.184, 0.000, 0.250}, {0.000, 0.868, 0.345, 19.577, 0.301, 0.286, 0.439, 0.420, 0.355, 0.653, 0.349, 0.642, 0.611, 0.398, 0.380, 0.366, 0.309, 0.738, 0.741, 0.756, 0.450, 0.750, 0.434, 0.317, 0.000, 0.250}, {0.000, 0.545, 4.743, 0.301, 7.398, 1.688, 0.299, 0.634, 0.679, 0.339, 0.784, 0.287, 0.346, 1.554, 0.599, 0.897, 0.573, 0.913, 0.695, 0.337, 0.232, 0.750, 0.346, 1.382, 0.000, 0.250}, {0.000, 0.741, 1.335, 0.286, 1.688, 5.470, 0.331, 0.481, 0.960, 0.331, 1.308, 0.373, 0.500, 0.911, 0.679, 1.902, 0.961, 0.950, 0.741, 0.429, 0.374, 0.750, 0.496, 4.090, 0.000, 0.250}, {0.000, 0.465, 0.324, 0.439, 0.299, 0.331, 8.129, 0.341, 0.652, 0.946, 0.344, 1.155, 1.004, 0.354, 0.287, 0.334, 0.381, 0.440, 0.482, 0.745, 1.374, 0.750, 2.769, 0.332, 0.000, 0.250}, {0.000, 1.057, 0.739, 0.420, 0.634, 0.481, 0.341, 6.876, 0.493, 0.275, 0.589, 0.284, 0.396, 0.864, 0.477, 0.539, 0.450, 0.904, 0.579, 0.337, 0.422, 0.750, 0.349, 0.503, 0.000, 0.250}, {0.000, 0.569, 0.925, 0.355, 0.679, 0.960, 0.652, 0.493, 13.506, 0.326, 0.779, 0.381, 0.584, 1.222, 0.473, 1.168, 0.917, 0.737, 0.557, 0.339, 0.444, 0.750, 1.798, 1.040, 0.000, 0.250}, {0.000, 0.632, 0.334, 0.653, 0.339, 0.331, 0.946, 0.275, 0.326, 3.998, 0.396, 1.694, 1.478, 0.328, 0.385, 0.383, 0.355, 0.443, 0.780, 2.417, 0.409, 0.750, 0.630, 0.351, 0.000, 0.250}, {0.000, 0.775, 0.855, 0.349, 0.784, 1.308, 0.344, 0.589, 0.779, 0.396, 4.764, 0.428, 0.625, 0.940, 0.704, 1.554, 2.077, 0.932, 0.793, 0.457, 0.359, 0.750, 0.532, 1.403, 0.000, 0.250}, {0.000, 0.602, 0.297, 0.642, 0.287, 0.373, 1.155, 0.284, 0.381, 1.694, 0.428, 3.797, 1.994, 0.310, 0.371, 0.477, 0.474, 0.429, 0.660, 1.314, 0.568, 0.750, 0.692, 0.413, 0.000, 0.250}, {0.000, 0.723, 0.405, 0.611, 0.346, 0.500, 1.004, 0.396, 0.584, 1.478, 0.625, 1.994, 6.481, 0.474, 0.424, 0.864, 0.623, 0.599, 0.794, 1.269, 0.610, 0.750, 0.708, 0.641, 0.000, 0.250}, {0.000, 0.588, 4.071, 0.398, 1.554, 0.911, 0.354, 0.864, 1.222, 0.328, 0.940, 0.310, 0.474, 7.094, 0.500, 1.001, 0.859, 1.232, 0.984, 0.369, 0.278, 0.750, 0.486, 0.946, 0.000, 0.250}, {0.000, 0.754, 0.554, 0.380, 0.599, 0.679, 0.287, 0.477, 0.473, 0.385, 0.704, 0.371, 0.424, 0.500, 12.838, 0.641, 0.481, 0.755, 0.689, 0.443, 0.282, 0.750, 0.363, 0.664, 0.000, 0.250}, {0.000, 0.757, 0.944, 0.366, 0.897, 1.902, 0.334, 0.539, 1.168, 0.383, 1.554, 0.477, 0.864, 1.001, 0.641, 6.244, 1.406, 0.966, 0.791, 0.467, 0.509, 0.750, 0.611, 3.582, 0.000, 0.250}, {0.000, 0.613, 0.703, 0.309, 0.573, 0.961, 0.381, 0.450, 0.917, 0.355, 2.077, 0.474, 0.623, 0.859, 0.481, 1.406, 6.666, 0.767, 0.678, 0.420, 0.395, 0.750, 0.556, 1.133, 0.000, 0.250}, {0.000, 1.472, 1.058, 0.738, 0.913, 0.950, 0.440, 0.904, 0.737, 0.443, 0.932, 0.429, 0.599, 1.232, 0.755, 0.966, 0.767, 3.843, 1.614, 0.565, 0.385, 0.750, 0.557, 0.956, 0.000, 0.250}, {0.000, 0.984, 0.826, 0.741, 0.695, 0.741, 0.482, 0.579, 0.557, 0.780, 0.793, 0.660, 0.794, 0.984, 0.689, 0.791, 0.678, 1.614, 4.832, 0.981, 0.431, 0.750, 0.573, 0.761, 0.000, 0.250}, {0.000, 0.936, 0.351, 0.756, 0.337, 0.429, 0.745, 0.337, 0.339, 2.417, 0.457, 1.314, 1.269, 0.369, 0.443, 0.467, 0.420, 0.565, 0.981, 3.692, 0.374, 0.750, 0.658, 0.444, 0.000, 0.250}, {0.000, 0.416, 0.253, 0.450, 0.232, 0.374, 1.374, 0.422, 0.444, 0.409, 0.359, 0.568, 0.610, 0.278, 0.282, 0.509, 0.395, 0.385, 0.431, 0.374, 38.108, 0.750, 2.110, 0.426, 0.000, 0.250}, {0.000, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.000, 0.250}, {0.000, 0.543, 0.409, 0.434, 0.346, 0.496, 2.769, 0.349, 1.798, 0.630, 0.532, 0.692, 0.708, 0.486, 0.363, 0.611, 0.556, 0.557, 0.573, 0.658, 2.110, 0.750, 9.832, 0.541, 0.000, 0.250}, {0.000, 0.747, 1.184, 0.317, 1.382, 4.090, 0.332, 0.503, 1.040, 0.351, 1.403, 0.413, 0.641, 0.946, 0.664, 3.582, 1.133, 0.956, 0.761, 0.444, 0.426, 0.750, 0.541, 3.893, 0.000, 0.250}, {0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.250}, {0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 0.250, 1.333}, }; static Nlm_FloatHi PAM30_FREQRATIOS[PROTEIN_ALPHABET][PROTEIN_ALPHABET] = { {0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.003}, {0.000, 7.789, 0.302, 0.108, 0.317, 0.453, 0.057, 0.576, 0.083, 0.199, 0.095, 0.115, 0.189, 0.285, 0.593, 0.235, 0.091, 0.875, 0.827, 0.477, 0.010, 0.750, 0.070, 0.358, 0.000, 0.003}, {0.000, 0.302, 8.118, 0.015, 8.456, 1.472, 0.027, 0.338, 0.664, 0.126, 0.441, 0.049, 0.034, 7.726, 0.102, 0.368, 0.082, 0.604, 0.353, 0.067, 0.032, 0.750, 0.114, 0.991, 0.000, 0.003}, {0.000, 0.108, 0.015, 27.591, 0.008, 0.008, 0.012, 0.042, 0.078, 0.119, 0.008, 0.006, 0.009, 0.024, 0.063, 0.008, 0.068, 0.379, 0.068, 0.132, 0.005, 0.750, 0.258, 0.008, 0.000, 0.003}, {0.000, 0.317, 8.456, 0.008, 14.236, 2.342, 0.006, 0.326, 0.271, 0.080, 0.220, 0.014, 0.023, 1.756, 0.068, 0.427, 0.029, 0.286, 0.200, 0.065, 0.005, 0.750, 0.020, 1.508, 0.000, 0.003}, {0.000, 0.453, 1.472, 0.008, 2.343, 13.663, 0.008, 0.232, 0.181, 0.150, 0.226, 0.043, 0.092, 0.464, 0.153, 1.507, 0.043, 0.226, 0.130, 0.110, 0.003, 0.750, 0.057, 8.365, 0.000, 0.003}, {0.000, 0.057, 0.027, 0.012, 0.006, 0.008, 21.408, 0.044, 0.132, 0.473, 0.009, 0.416, 0.250, 0.051, 0.036, 0.011, 0.042, 0.114, 0.051, 0.067, 0.213, 0.750, 1.786, 0.009, 0.000, 0.003}, {0.000, 0.576, 0.338, 0.042, 0.326, 0.232, 0.044, 9.314, 0.048, 0.024, 0.086, 0.028, 0.057, 0.351, 0.122, 0.094, 0.040, 0.553, 0.135, 0.149, 0.006, 0.750, 0.009, 0.172, 0.000, 0.003}, {0.000, 0.083, 0.664, 0.078, 0.271, 0.181, 0.132, 0.048, 22.927, 0.044, 0.120, 0.123, 0.028, 1.119, 0.248, 1.359, 0.587, 0.132, 0.086, 0.115, 0.081, 0.750, 0.324, 0.695, 0.000, 0.003}, {0.000, 0.199, 0.126, 0.119, 0.080, 0.150, 0.473, 0.024, 0.044, 18.632, 0.127, 0.643, 0.793, 0.179, 0.053, 0.070, 0.159, 0.097, 0.444, 1.938, 0.009, 0.750, 0.119, 0.115, 0.000, 0.003}, {0.000, 0.095, 0.441, 0.008, 0.220, 0.226, 0.009, 0.086, 0.120, 0.127, 9.988, 0.061, 0.563, 0.697, 0.106, 0.384, 1.111, 0.260, 0.336, 0.046, 0.018, 0.750, 0.042, 0.295, 0.000, 0.003}, {0.000, 0.115, 0.049, 0.006, 0.014, 0.043, 0.416, 0.028, 0.123, 0.643, 0.061, 10.019, 1.242, 0.090, 0.090, 0.185, 0.053, 0.058, 0.103, 0.463, 0.127, 0.750, 0.095, 0.105, 0.000, 0.003}, {0.000, 0.189, 0.034, 0.009, 0.023, 0.092, 0.250, 0.057, 0.028, 0.792, 0.563, 1.242, 46.604, 0.047, 0.065, 0.272, 0.243, 0.161, 0.263, 0.631, 0.013, 0.750, 0.021, 0.171, 0.000, 0.003}, {0.000, 0.285, 7.726, 0.024, 1.756, 0.464, 0.051, 0.351, 1.119, 0.179, 0.697, 0.090, 0.047, 14.647, 0.142, 0.299, 0.144, 0.972, 0.531, 0.070, 0.064, 0.750, 0.223, 0.392, 0.000, 0.003}, {0.000, 0.593, 0.102, 0.063, 0.068, 0.153, 0.036, 0.122, 0.248, 0.053, 0.106, 0.090, 0.065, 0.142, 15.809, 0.376, 0.270, 0.571, 0.240, 0.140, 0.009, 0.750, 0.010, 0.251, 0.000, 0.003}, {0.000, 0.235, 0.368, 0.008, 0.427, 1.507, 0.011, 0.094, 1.360, 0.070, 0.384, 0.185, 0.272, 0.299, 0.376, 18.136, 0.585, 0.168, 0.150, 0.103, 0.012, 0.750, 0.017, 8.754, 0.000, 0.003}, {0.000, 0.091, 0.082, 0.068, 0.029, 0.043, 0.042, 0.040, 0.587, 0.159, 1.111, 0.053, 0.243, 0.144, 0.270, 0.585, 18.926, 0.355, 0.106, 0.074, 0.517, 0.750, 0.030, 0.279, 0.000, 0.003}, {0.000, 0.875, 0.604, 0.379, 0.286, 0.226, 0.114, 0.553, 0.132, 0.097, 0.260, 0.058, 0.161, 0.972, 0.571, 0.168, 0.355, 9.028, 1.145, 0.118, 0.179, 0.750, 0.097, 0.200, 0.000, 0.003}, {0.000, 0.827, 0.353, 0.068, 0.200, 0.130, 0.051, 0.135, 0.086, 0.444, 0.336, 0.103, 0.263, 0.531, 0.240, 0.150, 0.106, 1.145, 11.695, 0.391, 0.013, 0.750, 0.112, 0.139, 0.000, 0.003}, {0.000, 0.477, 0.067, 0.132, 0.065, 0.110, 0.067, 0.149, 0.115, 1.938, 0.046, 0.463, 0.631, 0.070, 0.141, 0.103, 0.074, 0.118, 0.391, 11.609, 0.005, 0.750, 0.081, 0.107, 0.000, 0.003}, {0.000, 0.010, 0.032, 0.005, 0.005, 0.003, 0.213, 0.006, 0.081, 0.009, 0.018, 0.127, 0.013, 0.064, 0.009, 0.012, 0.517, 0.179, 0.013, 0.005, 88.722, 0.750, 0.173, 0.007, 0.000, 0.003}, {0.000, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.000, 0.003}, {0.000, 0.070, 0.114, 0.258, 0.020, 0.057, 1.786, 0.009, 0.324, 0.119, 0.042, 0.095, 0.021, 0.223, 0.010, 0.017, 0.030, 0.097, 0.112, 0.081, 0.173, 0.750, 28.442, 0.039, 0.000, 0.003}, {0.000, 0.358, 0.991, 0.008, 1.508, 8.365, 0.009, 0.172, 0.695, 0.115, 0.295, 0.105, 0.171, 0.392, 0.251, 8.754, 0.279, 0.200, 0.139, 0.107, 0.007, 0.750, 0.039, 8.535, 0.000, 0.003}, {0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.003}, {0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 0.003, 1.333}, }; static Nlm_FloatHi PAM70_FREQRATIOS[PROTEIN_ALPHABET][PROTEIN_ALPHABET] = { {0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.002}, {0.000, 4.900, 0.605, 0.242, 0.619, 0.771, 0.135, 1.015, 0.221, 0.434, 0.249, 0.250, 0.376, 0.589, 1.030, 0.466, 0.227, 1.350, 1.327, 0.809, 0.043, 0.750, 0.154, 0.638, 0.000, 0.002}, {0.000, 0.605, 5.422, 0.066, 5.890, 2.249, 0.079, 0.649, 1.099, 0.253, 0.778, 0.120, 0.140, 4.879, 0.274, 0.790, 0.253, 0.955, 0.654, 0.185, 0.078, 0.750, 0.223, 1.613, 0.000, 0.002}, {0.000, 0.242, 0.066, 24.836, 0.040, 0.039, 0.055, 0.116, 0.165, 0.246, 0.038, 0.030, 0.044, 0.097, 0.159, 0.039, 0.151, 0.665, 0.186, 0.274, 0.022, 0.750, 0.523, 0.039, 0.000, 0.002}, {0.000, 0.618, 5.890, 0.040, 8.900, 3.357, 0.034, 0.639, 0.600, 0.193, 0.484, 0.064, 0.103, 2.400, 0.213, 0.922, 0.139, 0.600, 0.442, 0.173, 0.026, 0.750, 0.080, 2.296, 0.000, 0.002}, {0.000, 0.771, 2.249, 0.039, 3.357, 8.654, 0.038, 0.492, 0.480, 0.284, 0.466, 0.117, 0.212, 0.965, 0.347, 2.258, 0.179, 0.479, 0.338, 0.247, 0.019, 0.750, 0.119, 5.867, 0.000, 0.002}, {0.000, 0.135, 0.079, 0.055, 0.034, 0.038, 17.455, 0.100, 0.277, 0.846, 0.041, 0.824, 0.508, 0.131, 0.089, 0.052, 0.099, 0.216, 0.138, 0.208, 0.452, 0.750, 3.378, 0.044, 0.000, 0.002}, {0.000, 1.015, 0.649, 0.116, 0.639, 0.492, 0.100, 7.309, 0.145, 0.107, 0.210, 0.081, 0.144, 0.660, 0.308, 0.237, 0.122, 0.964, 0.370, 0.313, 0.027, 0.750, 0.044, 0.381, 0.000, 0.002}, {0.000, 0.221, 1.099, 0.165, 0.600, 0.480, 0.277, 0.145, 16.422, 0.140, 0.335, 0.259, 0.122, 1.677, 0.493, 2.188, 1.058, 0.327, 0.230, 0.233, 0.186, 0.750, 0.611, 1.224, 0.000, 0.002}, {0.000, 0.434, 0.253, 0.246, 0.193, 0.284, 0.846, 0.107, 0.140, 11.749, 0.266, 1.192, 1.369, 0.322, 0.160, 0.189, 0.301, 0.254, 0.761, 3.004, 0.044, 0.750, 0.281, 0.242, 0.000, 0.002}, {0.000, 0.249, 0.778, 0.038, 0.484, 0.466, 0.041, 0.210, 0.335, 0.266, 7.610, 0.153, 0.948, 1.119, 0.256, 0.722, 1.937, 0.520, 0.620, 0.139, 0.079, 0.750, 0.101, 0.578, 0.000, 0.002}, {0.000, 0.250, 0.120, 0.030, 0.064, 0.117, 0.824, 0.081, 0.259, 1.192, 0.153, 8.228, 2.130, 0.185, 0.199, 0.351, 0.137, 0.149, 0.240, 0.908, 0.267, 0.750, 0.239, 0.219, 0.000, 0.002}, {0.000, 0.376, 0.140, 0.044, 0.103, 0.212, 0.508, 0.144, 0.122, 1.369, 0.948, 2.129, 28.592, 0.182, 0.176, 0.486, 0.488, 0.319, 0.498, 1.133, 0.060, 0.750, 0.097, 0.332, 0.000, 0.002}, {0.000, 0.589, 4.879, 0.097, 2.400, 0.965, 0.131, 0.660, 1.677, 0.322, 1.119, 0.185, 0.182, 7.754, 0.344, 0.637, 0.387, 1.366, 0.899, 0.199, 0.138, 0.750, 0.390, 0.822, 0.000, 0.002}, {0.000, 1.030, 0.274, 0.159, 0.213, 0.347, 0.089, 0.308, 0.493, 0.160, 0.256, 0.199, 0.176, 0.344, 11.871, 0.684, 0.527, 0.979, 0.531, 0.307, 0.042, 0.750, 0.047, 0.494, 0.000, 0.002}, {0.000, 0.466, 0.790, 0.039, 0.923, 2.258, 0.052, 0.237, 2.188, 0.189, 0.722, 0.351, 0.486, 0.637, 0.684, 11.469, 1.024, 0.373, 0.329, 0.232, 0.055, 0.750, 0.074, 6.272, 0.000, 0.002}, {0.000, 0.227, 0.253, 0.151, 0.139, 0.179, 0.099, 0.122, 1.058, 0.301, 1.937, 0.137, 0.488, 0.387, 0.527, 1.024, 13.660, 0.610, 0.284, 0.176, 0.991, 0.750, 0.086, 0.547, 0.000, 0.002}, {0.000, 1.350, 0.955, 0.665, 0.600, 0.479, 0.216, 0.964, 0.327, 0.254, 0.520, 0.149, 0.319, 1.366, 0.979, 0.373, 0.610, 5.204, 1.695, 0.303, 0.324, 0.750, 0.208, 0.433, 0.000, 0.002}, {0.000, 1.327, 0.654, 0.186, 0.442, 0.338, 0.138, 0.370, 0.230, 0.761, 0.620, 0.240, 0.498, 0.899, 0.531, 0.329, 0.284, 1.695, 7.337, 0.719, 0.055, 0.750, 0.228, 0.334, 0.000, 0.002}, {0.000, 0.809, 0.185, 0.275, 0.173, 0.247, 0.208, 0.313, 0.233, 3.003, 0.139, 0.908, 1.133, 0.199, 0.307, 0.232, 0.176, 0.303, 0.719, 8.211, 0.027, 0.750, 0.181, 0.240, 0.000, 0.002}, {0.000, 0.043, 0.078, 0.022, 0.026, 0.019, 0.452, 0.027, 0.186, 0.044, 0.079, 0.267, 0.060, 0.138, 0.042, 0.055, 0.991, 0.324, 0.054, 0.027, 80.645, 0.750, 0.377, 0.035, 0.000, 0.002}, {0.000, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.000, 0.002}, {0.000, 0.154, 0.223, 0.523, 0.080, 0.119, 3.379, 0.044, 0.611, 0.281, 0.101, 0.239, 0.097, 0.390, 0.047, 0.074, 0.086, 0.208, 0.228, 0.181, 0.377, 0.750, 23.141, 0.099, 0.000, 0.002}, {0.000, 0.638, 1.613, 0.039, 2.296, 5.867, 0.044, 0.381, 1.224, 0.242, 0.578, 0.219, 0.332, 0.822, 0.494, 6.272, 0.547, 0.433, 0.334, 0.240, 0.035, 0.750, 0.099, 6.043, 0.000, 0.002}, {0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.002}, {0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 0.002, 1.333}, }; static Nlm_FloatHi BLOSUM45_FREQRATIOS[PROTEIN_ALPHABET][PROTEIN_ALPHABET] = { {0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.290}, {0.000, 2.950, 0.735, 0.800, 0.689, 0.825, 0.587, 1.080, 0.654, 0.747, 0.786, 0.712, 0.821, 0.789, 0.709, 0.867, 0.700, 1.300, 1.001, 1.010, 0.565, 0.750, 0.639, 0.841, 0.000, 0.290}, {0.000, 0.735, 3.260, 0.600, 3.594, 1.300, 0.496, 0.886, 1.088, 0.497, 1.023, 0.472, 0.580, 2.862, 0.686, 0.992, 0.829, 1.053, 0.985, 0.520, 0.381, 0.750, 0.627, 1.182, 0.000, 0.290}, {0.000, 0.800, 0.600, 17.090, 0.533, 0.545, 0.602, 0.557, 0.491, 0.543, 0.547, 0.673, 0.604, 0.680, 0.411, 0.486, 0.472, 0.797, 0.822, 0.715, 0.334, 0.750, 0.489, 0.523, 0.000, 0.290}, {0.000, 0.689, 3.594, 0.533, 5.356, 1.643, 0.431, 0.740, 0.976, 0.440, 0.942, 0.463, 0.494, 1.502, 0.724, 0.958, 0.771, 0.929, 0.876, 0.494, 0.373, 0.750, 0.645, 1.381, 0.000, 0.290}, {0.000, 0.825, 1.300, 0.545, 1.643, 3.873, 0.498, 0.576, 0.962, 0.485, 1.277, 0.571, 0.615, 0.893, 0.911, 1.531, 1.011, 0.912, 0.833, 0.555, 0.519, 0.750, 0.617, 2.978, 0.000, 0.290}, {0.000, 0.587, 0.496, 0.602, 0.431, 0.498, 5.748, 0.480, 0.679, 1.064, 0.529, 1.303, 1.063, 0.572, 0.451, 0.444, 0.590, 0.610, 0.716, 0.953, 1.355, 0.750, 2.185, 0.477, 0.000, 0.290}, {0.000, 1.080, 0.886, 0.557, 0.740, 0.576, 0.480, 5.071, 0.662, 0.416, 0.678, 0.450, 0.585, 1.059, 0.702, 0.687, 0.570, 1.058, 0.693, 0.479, 0.591, 0.750, 0.549, 0.619, 0.000, 0.290}, {0.000, 0.654, 1.088, 0.491, 0.976, 0.962, 0.679, 0.662, 9.512, 0.453, 0.890, 0.670, 0.918, 1.220, 0.661, 1.151, 0.973, 0.854, 0.706, 0.457, 0.452, 0.750, 1.472, 1.034, 0.000, 0.290}, {0.000, 0.747, 0.497, 0.543, 0.440, 0.485, 1.064, 0.416, 0.453, 3.233, 0.532, 1.596, 1.455, 0.564, 0.610, 0.578, 0.488, 0.618, 0.848, 2.176, 0.565, 0.750, 0.906, 0.521, 0.000, 0.290}, {0.000, 0.786, 1.023, 0.547, 0.942, 1.277, 0.529, 0.678, 0.890, 0.532, 3.327, 0.554, 0.738, 1.119, 0.781, 1.330, 1.943, 0.890, 0.885, 0.592, 0.562, 0.750, 0.737, 1.297, 0.000, 0.290}, {0.000, 0.712, 0.472, 0.673, 0.463, 0.571, 1.303, 0.450, 0.670, 1.596, 0.554, 2.997, 1.731, 0.484, 0.478, 0.642, 0.601, 0.556, 0.781, 1.334, 0.671, 0.750, 0.965, 0.598, 0.000, 0.290}, {0.000, 0.821, 0.580, 0.604, 0.494, 0.615, 1.063, 0.585, 0.918, 1.455, 0.738, 1.731, 4.114, 0.682, 0.644, 0.941, 0.776, 0.660, 0.860, 1.236, 0.634, 0.750, 1.023, 0.739, 0.000, 0.290}, {0.000, 0.789, 2.862, 0.680, 1.502, 0.893, 0.572, 1.059, 1.220, 0.564, 1.119, 0.484, 0.682, 4.478, 0.640, 1.032, 0.898, 1.200, 1.115, 0.552, 0.390, 0.750, 0.606, 0.946, 0.000, 0.290}, {0.000, 0.709, 0.686, 0.411, 0.724, 0.911, 0.451, 0.702, 0.661, 0.610, 0.781, 0.478, 0.644, 0.640, 8.819, 0.716, 0.582, 0.750, 0.856, 0.540, 0.525, 0.750, 0.479, 0.836, 0.000, 0.290}, {0.000, 0.867, 0.992, 0.486, 0.958, 1.531, 0.444, 0.687, 1.151, 0.578, 1.330, 0.642, 0.941, 1.032, 0.716, 4.407, 1.329, 1.092, 0.781, 0.547, 0.645, 0.750, 0.829, 2.630, 0.000, 0.290}, {0.000, 0.700, 0.829, 0.472, 0.771, 1.011, 0.590, 0.570, 0.973, 0.488, 1.943, 0.601, 0.776, 0.898, 0.582, 1.329, 4.747, 0.799, 0.715, 0.578, 0.580, 0.750, 0.807, 1.132, 0.000, 0.290}, {0.000, 1.300, 1.053, 0.797, 0.929, 0.912, 0.610, 1.058, 0.854, 0.618, 0.890, 0.556, 0.660, 1.200, 0.750, 1.092, 0.799, 2.782, 1.472, 0.728, 0.428, 0.750, 0.706, 0.981, 0.000, 0.290}, {0.000, 1.001, 0.985, 0.822, 0.876, 0.833, 0.716, 0.693, 0.706, 0.848, 0.885, 0.781, 0.860, 1.115, 0.856, 0.781, 0.715, 1.472, 3.139, 1.040, 0.454, 0.750, 0.744, 0.813, 0.000, 0.290}, {0.000, 1.010, 0.520, 0.715, 0.494, 0.555, 0.953, 0.479, 0.457, 2.176, 0.592, 1.334, 1.236, 0.552, 0.540, 0.547, 0.578, 0.728, 1.040, 2.871, 0.473, 0.750, 0.809, 0.552, 0.000, 0.290}, {0.000, 0.565, 0.381, 0.334, 0.373, 0.519, 1.355, 0.591, 0.452, 0.565, 0.562, 0.671, 0.634, 0.390, 0.525, 0.645, 0.580, 0.428, 0.454, 0.473, 29.702, 0.750, 1.801, 0.567, 0.000, 0.290}, {0.000, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.000, 0.290}, {0.000, 0.639, 0.627, 0.489, 0.645, 0.617, 2.185, 0.549, 1.472, 0.906, 0.737, 0.965, 1.023, 0.606, 0.479, 0.829, 0.807, 0.706, 0.744, 0.809, 1.801, 0.750, 5.753, 0.698, 0.000, 0.290}, {0.000, 0.841, 1.182, 0.523, 1.381, 2.978, 0.477, 0.619, 1.034, 0.521, 1.297, 0.598, 0.739, 0.946, 0.836, 2.630, 1.132, 0.981, 0.813, 0.552, 0.567, 0.750, 0.698, 2.845, 0.000, 0.290}, {0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.290}, {0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 1.333}, }; static Nlm_FloatHi BLOSUM80_FREQRATIOS[PROTEIN_ALPHABET][PROTEIN_ALPHABET] = { {0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.140}, {0.000, 4.773, 0.477, 0.732, 0.451, 0.703, 0.397, 0.957, 0.514, 0.543, 0.723, 0.505, 0.625, 0.510, 0.771, 0.696, 0.555, 1.535, 0.980, 0.866, 0.309, 0.750, 0.436, 0.700, 0.000, 0.140}, {0.000, 0.477, 5.362, 0.252, 5.759, 1.269, 0.252, 0.639, 0.830, 0.234, 0.793, 0.221, 0.310, 4.868, 0.428, 0.850, 0.609, 0.948, 0.743, 0.268, 0.179, 0.750, 0.307, 1.109, 0.000, 0.140}, {0.000, 0.732, 0.252, 20.702, 0.214, 0.180, 0.395, 0.272, 0.221, 0.581, 0.241, 0.493, 0.499, 0.300, 0.269, 0.295, 0.233, 0.576, 0.602, 0.634, 0.302, 0.750, 0.308, 0.224, 0.000, 0.140}, {0.000, 0.451, 5.759, 0.214, 9.106, 1.635, 0.234, 0.541, 0.594, 0.214, 0.677, 0.197, 0.252, 1.584, 0.452, 0.763, 0.477, 0.774, 0.611, 0.245, 0.145, 0.750, 0.245, 1.303, 0.000, 0.140}, {0.000, 0.703, 1.269, 0.180, 1.635, 6.995, 0.249, 0.399, 0.901, 0.264, 1.195, 0.276, 0.429, 0.811, 0.581, 1.906, 0.832, 0.845, 0.685, 0.369, 0.241, 0.750, 0.333, 5.054, 0.000, 0.140}, {0.000, 0.397, 0.252, 0.395, 0.234, 0.249, 9.486, 0.249, 0.572, 0.841, 0.283, 1.114, 0.893, 0.273, 0.237, 0.285, 0.287, 0.369, 0.445, 0.649, 1.089, 0.750, 2.780, 0.263, 0.000, 0.140}, {0.000, 0.957, 0.639, 0.272, 0.541, 0.399, 0.249, 7.882, 0.387, 0.184, 0.483, 0.210, 0.286, 0.761, 0.347, 0.425, 0.377, 0.784, 0.492, 0.251, 0.264, 0.750, 0.230, 0.409, 0.000, 0.140}, {0.000, 0.514, 0.830, 0.221, 0.594, 0.901, 0.572, 0.387, 16.070, 0.258, 0.740, 0.314, 0.432, 1.124, 0.420, 1.316, 0.925, 0.661, 0.540, 0.289, 0.390, 0.750, 1.819, 1.059, 0.000, 0.140}, {0.000, 0.543, 0.234, 0.581, 0.214, 0.264, 0.841, 0.184, 0.258, 4.868, 0.313, 1.665, 1.512, 0.258, 0.286, 0.309, 0.299, 0.379, 0.701, 2.496, 0.343, 0.750, 0.539, 0.281, 0.000, 0.140}, {0.000, 0.723, 0.793, 0.241, 0.677, 1.195, 0.283, 0.483, 0.740, 0.313, 6.326, 0.357, 0.534, 0.938, 0.597, 1.524, 2.192, 0.820, 0.736, 0.370, 0.241, 0.750, 0.408, 1.320, 0.000, 0.140}, {0.000, 0.505, 0.221, 0.493, 0.197, 0.276, 1.114, 0.210, 0.314, 1.665, 0.357, 4.463, 2.123, 0.250, 0.303, 0.407, 0.363, 0.368, 0.561, 1.220, 0.439, 0.750, 0.581, 0.326, 0.000, 0.140}, {0.000, 0.625, 0.310, 0.499, 0.252, 0.429, 0.893, 0.286, 0.432, 1.512, 0.534, 2.123, 8.883, 0.382, 0.362, 0.887, 0.506, 0.498, 0.758, 1.224, 0.561, 0.750, 0.550, 0.603, 0.000, 0.140}, {0.000, 0.510, 4.868, 0.300, 1.584, 0.811, 0.273, 0.761, 1.124, 0.258, 0.938, 0.250, 0.382, 8.963, 0.398, 0.958, 0.773, 1.165, 0.908, 0.297, 0.221, 0.750, 0.385, 0.867, 0.000, 0.140}, {0.000, 0.771, 0.428, 0.269, 0.452, 0.581, 0.237, 0.347, 0.420, 0.286, 0.597, 0.303, 0.362, 0.398, 15.155, 0.538, 0.446, 0.652, 0.560, 0.370, 0.178, 0.750, 0.258, 0.565, 0.000, 0.140}, {0.000, 0.696, 0.850, 0.295, 0.763, 1.906, 0.285, 0.425, 1.316, 0.309, 1.524, 0.407, 0.887, 0.958, 0.538, 8.340, 1.394, 0.859, 0.724, 0.411, 0.408, 0.750, 0.462, 4.360, 0.000, 0.140}, {0.000, 0.555, 0.609, 0.233, 0.477, 0.832, 0.287, 0.377, 0.925, 0.299, 2.192, 0.363, 0.506, 0.773, 0.446, 1.394, 8.245, 0.695, 0.598, 0.354, 0.294, 0.750, 0.418, 1.046, 0.000, 0.140}, {0.000, 1.535, 0.948, 0.576, 0.774, 0.845, 0.369, 0.784, 0.661, 0.379, 0.820, 0.368, 0.498, 1.165, 0.652, 0.859, 0.695, 5.106, 1.663, 0.494, 0.271, 0.750, 0.462, 0.850, 0.000, 0.140}, {0.000, 0.980, 0.743, 0.602, 0.611, 0.685, 0.445, 0.492, 0.540, 0.701, 0.736, 0.561, 0.758, 0.908, 0.560, 0.724, 0.598, 1.663, 6.205, 0.891, 0.285, 0.750, 0.474, 0.700, 0.000, 0.140}, {0.000, 0.866, 0.268, 0.634, 0.245, 0.369, 0.649, 0.251, 0.289, 2.496, 0.370, 1.220, 1.224, 0.297, 0.370, 0.411, 0.354, 0.494, 0.891, 4.584, 0.342, 0.750, 0.489, 0.385, 0.000, 0.140}, {0.000, 0.309, 0.179, 0.302, 0.145, 0.241, 1.089, 0.264, 0.390, 0.343, 0.241, 0.439, 0.561, 0.221, 0.178, 0.408, 0.294, 0.271, 0.285, 0.342, 41.552, 0.750, 2.036, 0.304, 0.000, 0.140}, {0.000, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.000, 0.140}, {0.000, 0.436, 0.307, 0.308, 0.245, 0.333, 2.780, 0.230, 1.819, 0.539, 0.408, 0.581, 0.550, 0.385, 0.258, 0.462, 0.418, 0.462, 0.474, 0.489, 2.036, 0.750, 12.194, 0.382, 0.000, 0.140}, {0.000, 0.700, 1.109, 0.224, 1.303, 5.054, 0.263, 0.409, 1.059, 0.281, 1.320, 0.326, 0.603, 0.867, 0.565, 4.360, 1.046, 0.850, 0.700, 0.385, 0.304, 0.750, 0.382, 4.789, 0.000, 0.140}, {0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.140}, {0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 0.140, 1.333}, }; static Nlm_FloatHi BLOSUM50_FREQRATIOS[PROTEIN_ALPHABET][PROTEIN_ALPHABET] = { {0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.290}, {0.000, 3.273, 0.687, 0.888, 0.660, 0.797, 0.546, 1.101, 0.641, 0.715, 0.748, 0.657, 0.854, 0.720, 0.715, 0.820, 0.668, 1.364, 0.967, 0.982, 0.464, 0.750, 0.596, 0.806, 0.000, 0.290}, {0.000, 0.687, 3.676, 0.507, 4.021, 1.319, 0.384, 0.848, 1.118, 0.407, 0.968, 0.391, 0.516, 3.269, 0.661, 0.998, 0.759, 1.061, 0.955, 0.446, 0.339, 0.750, 0.556, 1.196, 0.000, 0.290}, {0.000, 0.888, 0.507, 18.231, 0.428, 0.456, 0.565, 0.524, 0.517, 0.587, 0.460, 0.650, 0.681, 0.601, 0.403, 0.481, 0.428, 0.830, 0.818, 0.809, 0.312, 0.750, 0.539, 0.466, 0.000, 0.290}, {0.000, 0.660, 4.021, 0.428, 6.112, 1.658, 0.337, 0.745, 0.884, 0.370, 0.890, 0.373, 0.435, 1.558, 0.710, 0.967, 0.678, 0.921, 0.825, 0.432, 0.307, 0.750, 0.504, 1.394, 0.000, 0.290}, {0.000, 0.797, 1.319, 0.456, 1.658, 4.437, 0.456, 0.540, 0.911, 0.416, 1.331, 0.478, 0.605, 0.920, 0.839, 1.671, 0.976, 0.882, 0.819, 0.479, 0.548, 0.750, 0.652, 3.380, 0.000, 0.290}, {0.000, 0.546, 0.384, 0.565, 0.337, 0.456, 6.636, 0.414, 0.755, 0.990, 0.445, 1.262, 1.052, 0.439, 0.376, 0.417, 0.462, 0.553, 0.570, 0.860, 1.348, 0.750, 2.424, 0.441, 0.000, 0.290}, {0.000, 1.101, 0.848, 0.524, 0.745, 0.540, 0.414, 5.792, 0.601, 0.370, 0.655, 0.377, 0.519, 0.969, 0.620, 0.641, 0.517, 0.999, 0.636, 0.403, 0.505, 0.750, 0.467, 0.579, 0.000, 0.290}, {0.000, 0.641, 1.118, 0.517, 0.884, 0.911, 0.755, 0.601, 10.449, 0.411, 0.946, 0.547, 0.760, 1.394, 0.582, 1.209, 0.982, 0.823, 0.653, 0.414, 0.475, 0.750, 1.570, 1.025, 0.000, 0.290}, {0.000, 0.715, 0.407, 0.587, 0.370, 0.416, 0.990, 0.370, 0.411, 3.411, 0.468, 1.697, 1.438, 0.451, 0.511, 0.503, 0.435, 0.546, 0.861, 2.313, 0.522, 0.750, 0.826, 0.449, 0.000, 0.290}, {0.000, 0.748, 0.968, 0.460, 0.890, 1.331, 0.445, 0.655, 0.946, 0.468, 3.881, 0.479, 0.685, 1.060, 0.764, 1.419, 2.065, 0.893, 0.845, 0.523, 0.462, 0.750, 0.668, 1.365, 0.000, 0.290}, {0.000, 0.657, 0.391, 0.650, 0.373, 0.478, 1.262, 0.377, 0.547, 1.697, 0.479, 3.328, 1.790, 0.413, 0.444, 0.563, 0.554, 0.511, 0.759, 1.324, 0.602, 0.750, 0.858, 0.511, 0.000, 0.290}, {0.000, 0.854, 0.516, 0.681, 0.435, 0.605, 1.052, 0.519, 0.760, 1.438, 0.685, 1.790, 4.816, 0.612, 0.545, 0.960, 0.678, 0.682, 0.882, 1.213, 0.761, 0.750, 0.918, 0.741, 0.000, 0.290}, {0.000, 0.720, 3.269, 0.601, 1.558, 0.920, 0.439, 0.969, 1.394, 0.451, 1.060, 0.413, 0.612, 5.285, 0.604, 1.035, 0.854, 1.224, 1.109, 0.463, 0.376, 0.750, 0.617, 0.964, 0.000, 0.290}, {0.000, 0.715, 0.661, 0.403, 0.710, 0.839, 0.376, 0.620, 0.582, 0.511, 0.764, 0.444, 0.545, 0.604, 10.204, 0.750, 0.519, 0.759, 0.749, 0.524, 0.420, 0.750, 0.468, 0.805, 0.000, 0.290}, {0.000, 0.820, 0.998, 0.481, 0.967, 1.671, 0.417, 0.641, 1.209, 0.503, 1.419, 0.563, 0.960, 1.035, 0.750, 4.697, 1.357, 1.069, 0.810, 0.557, 0.715, 0.750, 0.742, 2.828, 0.000, 0.290}, {0.000, 0.668, 0.759, 0.428, 0.678, 0.976, 0.462, 0.517, 0.982, 0.435, 2.065, 0.554, 0.678, 0.854, 0.519, 1.357, 5.378, 0.804, 0.737, 0.512, 0.529, 0.750, 0.727, 1.122, 0.000, 0.290}, {0.000, 1.364, 1.061, 0.830, 0.921, 0.882, 0.553, 0.999, 0.823, 0.546, 0.893, 0.511, 0.682, 1.224, 0.759, 1.069, 0.804, 3.143, 1.497, 0.679, 0.392, 0.750, 0.651, 0.953, 0.000, 0.290}, {0.000, 0.967, 0.955, 0.818, 0.825, 0.819, 0.570, 0.636, 0.653, 0.861, 0.845, 0.759, 0.882, 1.109, 0.749, 0.810, 0.737, 1.497, 3.553, 1.060, 0.503, 0.750, 0.691, 0.816, 0.000, 0.290}, {0.000, 0.982, 0.446, 0.809, 0.432, 0.479, 0.860, 0.403, 0.414, 2.313, 0.523, 1.324, 1.213, 0.463, 0.524, 0.557, 0.512, 0.679, 1.060, 3.118, 0.485, 0.750, 0.727, 0.509, 0.000, 0.290}, {0.000, 0.464, 0.339, 0.312, 0.307, 0.548, 1.348, 0.505, 0.475, 0.522, 0.462, 0.602, 0.761, 0.376, 0.420, 0.715, 0.529, 0.392, 0.503, 0.485, 31.361, 0.750, 1.765, 0.612, 0.000, 0.290}, {0.000, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.000, 0.290}, {0.000, 0.596, 0.556, 0.539, 0.504, 0.652, 2.424, 0.467, 1.570, 0.826, 0.668, 0.858, 0.918, 0.617, 0.468, 0.742, 0.727, 0.651, 0.691, 0.727, 1.765, 0.750, 6.893, 0.686, 0.000, 0.290}, {0.000, 0.806, 1.196, 0.466, 1.394, 3.380, 0.441, 0.579, 1.025, 0.449, 1.365, 0.511, 0.741, 0.964, 0.805, 2.828, 1.122, 0.953, 0.816, 0.509, 0.612, 0.750, 0.686, 3.169, 0.000, 0.290}, {0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.290}, {0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 0.290, 1.333}, }; static Nlm_FloatHi BLOSUM90_FREQRATIOS[PROTEIN_ALPHABET][PROTEIN_ALPHABET] = { {0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.120}, {0.000, 4.773, 0.477, 0.732, 0.451, 0.703, 0.397, 0.957, 0.514, 0.543, 0.723, 0.505, 0.625, 0.510, 0.771, 0.696, 0.555, 1.535, 0.980, 0.866, 0.309, 0.707, 0.436, 0.700, 0.000, 0.120}, {0.000, 0.477, 5.362, 0.252, 5.759, 1.269, 0.252, 0.639, 0.830, 0.234, 0.793, 0.221, 0.310, 4.868, 0.428, 0.850, 0.609, 0.948, 0.743, 0.268, 0.179, 0.707, 0.307, 1.109, 0.000, 0.120}, {0.000, 0.732, 0.252, 20.702, 0.214, 0.180, 0.395, 0.272, 0.221, 0.581, 0.241, 0.493, 0.499, 0.300, 0.269, 0.295, 0.233, 0.576, 0.602, 0.634, 0.302, 0.707, 0.308, 0.224, 0.000, 0.120}, {0.000, 0.451, 5.759, 0.214, 9.106, 1.635, 0.234, 0.541, 0.594, 0.214, 0.677, 0.197, 0.252, 1.584, 0.452, 0.763, 0.477, 0.774, 0.611, 0.245, 0.145, 0.707, 0.245, 1.303, 0.000, 0.120}, {0.000, 0.703, 1.269, 0.180, 1.635, 6.995, 0.249, 0.399, 0.901, 0.264, 1.195, 0.276, 0.429, 0.811, 0.581, 1.906, 0.832, 0.845, 0.685, 0.369, 0.241, 0.707, 0.333, 5.054, 0.000, 0.120}, {0.000, 0.397, 0.252, 0.395, 0.234, 0.249, 9.486, 0.249, 0.572, 0.841, 0.283, 1.114, 0.893, 0.273, 0.237, 0.285, 0.287, 0.369, 0.445, 0.649, 1.089, 0.707, 2.780, 0.263, 0.000, 0.120}, {0.000, 0.957, 0.639, 0.272, 0.541, 0.399, 0.249, 7.882, 0.387, 0.184, 0.483, 0.210, 0.286, 0.761, 0.347, 0.425, 0.377, 0.784, 0.492, 0.251, 0.264, 0.707, 0.230, 0.409, 0.000, 0.120}, {0.000, 0.514, 0.830, 0.221, 0.594, 0.901, 0.572, 0.387, 16.070, 0.258, 0.740, 0.314, 0.432, 1.124, 0.420, 1.316, 0.925, 0.661, 0.540, 0.289, 0.390, 0.707, 1.819, 1.059, 0.000, 0.120}, {0.000, 0.543, 0.234, 0.581, 0.214, 0.264, 0.841, 0.184, 0.258, 4.868, 0.313, 1.665, 1.512, 0.258, 0.286, 0.309, 0.299, 0.379, 0.701, 2.496, 0.343, 0.707, 0.539, 0.281, 0.000, 0.120}, {0.000, 0.723, 0.793, 0.241, 0.677, 1.195, 0.283, 0.483, 0.740, 0.313, 6.326, 0.357, 0.534, 0.938, 0.597, 1.524, 2.192, 0.820, 0.736, 0.370, 0.241, 0.707, 0.408, 1.320, 0.000, 0.120}, {0.000, 0.505, 0.221, 0.493, 0.197, 0.276, 1.114, 0.210, 0.314, 1.665, 0.357, 4.463, 2.123, 0.250, 0.303, 0.407, 0.363, 0.368, 0.561, 1.220, 0.439, 0.707, 0.581, 0.326, 0.000, 0.120}, {0.000, 0.625, 0.310, 0.499, 0.252, 0.429, 0.893, 0.286, 0.432, 1.512, 0.534, 2.123, 8.883, 0.382, 0.362, 0.887, 0.506, 0.498, 0.758, 1.224, 0.561, 0.707, 0.550, 0.603, 0.000, 0.120}, {0.000, 0.510, 4.868, 0.300, 1.584, 0.811, 0.273, 0.761, 1.124, 0.258, 0.938, 0.250, 0.382, 8.963, 0.398, 0.958, 0.773, 1.165, 0.908, 0.297, 0.221, 0.707, 0.385, 0.867, 0.000, 0.120}, {0.000, 0.771, 0.428, 0.269, 0.452, 0.581, 0.237, 0.347, 0.420, 0.286, 0.597, 0.303, 0.362, 0.398, 15.155, 0.538, 0.446, 0.652, 0.560, 0.370, 0.178, 0.707, 0.258, 0.565, 0.000, 0.120}, {0.000, 0.696, 0.850, 0.295, 0.763, 1.906, 0.285, 0.425, 1.316, 0.309, 1.524, 0.407, 0.887, 0.958, 0.538, 8.340, 1.394, 0.859, 0.724, 0.411, 0.408, 0.707, 0.462, 4.360, 0.000, 0.120}, {0.000, 0.555, 0.609, 0.233, 0.477, 0.832, 0.287, 0.377, 0.925, 0.299, 2.192, 0.363, 0.506, 0.773, 0.446, 1.394, 8.245, 0.695, 0.598, 0.354, 0.294, 0.707, 0.418, 1.046, 0.000, 0.120}, {0.000, 1.535, 0.948, 0.576, 0.774, 0.845, 0.369, 0.784, 0.661, 0.379, 0.820, 0.368, 0.498, 1.165, 0.652, 0.859, 0.695, 5.106, 1.663, 0.494, 0.271, 0.707, 0.462, 0.850, 0.000, 0.120}, {0.000, 0.980, 0.743, 0.602, 0.611, 0.685, 0.445, 0.492, 0.540, 0.701, 0.736, 0.561, 0.758, 0.908, 0.560, 0.724, 0.598, 1.663, 6.205, 0.891, 0.285, 0.707, 0.474, 0.700, 0.000, 0.120}, {0.000, 0.866, 0.268, 0.634, 0.245, 0.369, 0.649, 0.251, 0.289, 2.496, 0.370, 1.220, 1.224, 0.297, 0.370, 0.411, 0.354, 0.494, 0.891, 4.584, 0.342, 0.707, 0.489, 0.385, 0.000, 0.120}, {0.000, 0.309, 0.179, 0.302, 0.145, 0.241, 1.089, 0.264, 0.390, 0.343, 0.241, 0.439, 0.561, 0.221, 0.178, 0.408, 0.294, 0.271, 0.285, 0.342, 41.552, 0.707, 2.036, 0.304, 0.000, 0.120}, {0.000, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.707, 0.000, 0.120}, {0.000, 0.436, 0.307, 0.308, 0.245, 0.333, 2.780, 0.230, 1.819, 0.539, 0.408, 0.581, 0.550, 0.385, 0.258, 0.462, 0.418, 0.462, 0.474, 0.489, 2.036, 0.707, 12.194, 0.382, 0.000, 0.120}, {0.000, 0.700, 1.109, 0.224, 1.303, 5.054, 0.263, 0.409, 1.059, 0.281, 1.320, 0.326, 0.603, 0.867, 0.565, 4.360, 1.046, 0.850, 0.700, 0.385, 0.304, 0.707, 0.382, 4.789, 0.000, 0.120}, {0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.120}, {0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 0.120, 1.333}, }; static Nlm_FloatHi PAM250_FREQRATIOS[PROTEIN_ALPHABET][PROTEIN_ALPHABET] = { {0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.170}, {0.000, 1.516, 1.056, 0.627, 1.070, 1.075, 0.446, 1.339, 0.732, 0.889, 0.766, 0.646, 0.770, 1.040, 1.294, 0.903, 0.701, 1.290, 1.317, 1.045, 0.264, 0.750, 0.450, 1.000, 0.000, 0.170}, {0.000, 1.056, 1.843, 0.365, 2.052, 1.825, 0.354, 1.119, 1.297, 0.617, 1.130, 0.453, 0.605, 1.600, 0.846, 1.339, 0.862, 1.117, 1.032, 0.638, 0.297, 0.750, 0.486, 1.613, 0.000, 0.170}, {0.000, 0.627, 0.365, 15.630, 0.307, 0.295, 0.371, 0.459, 0.452, 0.588, 0.286, 0.248, 0.299, 0.433, 0.527, 0.289, 0.430, 0.990, 0.601, 0.639, 0.169, 0.750, 1.078, 0.293, 0.000, 0.170}, {0.000, 1.070, 2.052, 0.307, 2.433, 2.197, 0.274, 1.147, 1.173, 0.580, 1.020, 0.398, 0.548, 1.610, 0.806, 1.461, 0.743, 1.069, 0.968, 0.612, 0.213, 0.750, 0.369, 1.877, 0.000, 0.170}, {0.000, 1.075, 1.825, 0.295, 2.197, 2.414, 0.287, 1.044, 1.165, 0.626, 0.988, 0.464, 0.614, 1.393, 0.880, 1.771, 0.782, 0.999, 0.914, 0.660, 0.201, 0.750, 0.372, 2.134, 0.000, 0.170}, {0.000, 0.446, 0.354, 0.371, 0.274, 0.287, 8.028, 0.332, 0.659, 1.262, 0.298, 1.518, 1.043, 0.447, 0.351, 0.343, 0.359, 0.478, 0.488, 0.766, 1.077, 0.750, 4.975, 0.311, 0.000, 0.170}, {0.000, 1.339, 1.119, 0.459, 1.147, 1.044, 0.332, 2.991, 0.616, 0.557, 0.678, 0.395, 0.525, 1.087, 0.894, 0.757, 0.555, 1.278, 0.999, 0.735, 0.200, 0.750, 0.300, 0.919, 0.000, 0.170}, {0.000, 0.732, 1.297, 0.452, 1.173, 1.165, 0.660, 0.616, 4.475, 0.571, 0.990, 0.620, 0.610, 1.440, 0.947, 1.962, 1.431, 0.830, 0.741, 0.597, 0.544, 0.750, 0.979, 1.512, 0.000, 0.170}, {0.000, 0.889, 0.617, 0.588, 0.580, 0.626, 1.262, 0.557, 0.571, 2.830, 0.641, 1.749, 1.650, 0.660, 0.627, 0.625, 0.629, 0.723, 1.017, 2.338, 0.303, 0.750, 0.800, 0.626, 0.000, 0.170}, {0.000, 0.766, 1.130, 0.286, 1.020, 0.988, 0.298, 0.678, 0.990, 0.641, 2.926, 0.519, 1.100, 1.258, 0.770, 1.184, 2.182, 0.962, 0.996, 0.570, 0.451, 0.750, 0.360, 1.073, 0.000, 0.170}, {0.000, 0.646, 0.453, 0.248, 0.398, 0.464, 1.518, 0.395, 0.620, 1.749, 0.519, 3.930, 2.338, 0.516, 0.556, 0.665, 0.501, 0.524, 0.677, 1.532, 0.647, 0.750, 0.815, 0.551, 0.000, 0.170}, {0.000, 0.770, 0.605, 0.299, 0.548, 0.614, 1.043, 0.525, 0.609, 1.650, 1.100, 2.338, 4.404, 0.670, 0.621, 0.796, 0.905, 0.699, 0.873, 1.510, 0.375, 0.750, 0.568, 0.693, 0.000, 0.170}, {0.000, 1.040, 1.600, 0.433, 1.610, 1.393, 0.447, 1.087, 1.440, 0.660, 1.258, 0.516, 0.671, 1.588, 0.893, 1.197, 1.000, 1.173, 1.107, 0.668, 0.394, 0.750, 0.621, 1.307, 0.000, 0.170}, {0.000, 1.294, 0.846, 0.527, 0.806, 0.880, 0.351, 0.894, 0.946, 0.627, 0.770, 0.556, 0.621, 0.893, 3.841, 1.055, 0.960, 1.243, 1.076, 0.758, 0.275, 0.750, 0.321, 0.956, 0.000, 0.170}, {0.000, 0.903, 1.339, 0.290, 1.462, 1.772, 0.343, 0.757, 1.962, 0.625, 1.184, 0.665, 0.796, 1.197, 1.056, 2.541, 1.335, 0.890, 0.833, 0.649, 0.335, 0.750, 0.395, 2.107, 0.000, 0.170}, {0.000, 0.701, 0.862, 0.430, 0.743, 0.782, 0.359, 0.555, 1.430, 0.629, 2.182, 0.501, 0.905, 1.000, 0.960, 1.335, 4.078, 0.928, 0.820, 0.561, 1.652, 0.750, 0.379, 1.023, 0.000, 0.170}, {0.000, 1.290, 1.117, 0.990, 1.069, 0.999, 0.478, 1.278, 0.830, 0.722, 0.962, 0.524, 0.699, 1.173, 1.244, 0.890, 0.928, 1.441, 1.362, 0.799, 0.566, 0.750, 0.520, 0.951, 0.000, 0.170}, {0.000, 1.317, 1.032, 0.601, 0.968, 0.914, 0.488, 0.999, 0.741, 1.016, 0.996, 0.677, 0.873, 1.107, 1.075, 0.833, 0.820, 1.362, 1.806, 1.068, 0.306, 0.750, 0.530, 0.879, 0.000, 0.170}, {0.000, 1.045, 0.638, 0.639, 0.612, 0.660, 0.766, 0.735, 0.597, 2.338, 0.570, 1.532, 1.511, 0.668, 0.758, 0.649, 0.561, 0.799, 1.068, 2.698, 0.237, 0.750, 0.566, 0.656, 0.000, 0.170}, {0.000, 0.264, 0.297, 0.169, 0.213, 0.201, 1.077, 0.200, 0.544, 0.303, 0.450, 0.647, 0.375, 0.394, 0.275, 0.335, 1.651, 0.566, 0.306, 0.237, 52.679, 0.750, 0.970, 0.259, 0.000, 0.170}, {0.000, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.750, 0.000, 0.170}, {0.000, 0.450, 0.486, 1.078, 0.369, 0.372, 4.976, 0.300, 0.979, 0.800, 0.360, 0.815, 0.568, 0.621, 0.321, 0.395, 0.379, 0.520, 0.530, 0.566, 0.970, 0.750, 10.338, 0.382, 0.000, 0.170}, {0.000, 1.000, 1.613, 0.293, 1.877, 2.134, 0.311, 0.919, 1.512, 0.626, 1.073, 0.551, 0.693, 1.307, 0.956, 2.107, 1.023, 0.951, 0.879, 0.656, 0.259, 0.750, 0.382, 2.122, 0.000, 0.170}, {0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.000, 0.170}, {0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 0.170, 1.333}, }; #ifdef __cplusplus } #endif #endif /* __POSIT__ */